糖基合成3-氧基糖基和2-脱氧内酯的可转换反应性

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-08-25 DOI:10.1002/slct.202504180

Manish Kumar Sharma, Dr. Anand Kumar Pandey, Dr. Nazar Hussain

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引用次数: 0

摘要

通过在环境条件下直接由甘醛合成3-氧甘醛和2-脱氧内酯，证明了甘醛的可转换反应性。以（NH4）2S2O8为氧化剂，在DMSO溶剂中，在55℃下进行c3氧化制得3-氧基醛。在DMSO:H2O溶剂体系中，以Pd(OAc)2为催化剂，K2S2O8为氧化剂，采用C-1氧化法合成了2-脱氧内酯。该方法操作简单，产量高，可扩展，并且具有多种衬底范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Switchable Reactivity of Glycals Toward the Synthesis of 3-Oxo Glycals and 2-Deoxy Lactones

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Switchable Reactivity of Glycals Toward the Synthesis of 3-Oxo Glycals and 2-Deoxy Lactones

The switchable reactivity of glycals has been demonstrated by the successful synthesis of 3-oxo glycals and 2-deoxy lactones directly from glycals under ambient conditions. 3-Oxo glycals were obtained from various glycals via C3-oxidation employing (NH₄)₂S₂O₈ as an oxidant in DMSO solvent at 55 °C. However, 2-deoxy lactones were synthesized through C-1 oxidation using Pd(OAc)₂ as a catalyst and K₂S₂O₈ as an oxidant in the DMSO:H₂O solvent system. The methodology is operationally simple, high-yielding, scalable, and endowed with varied substrate scope.

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.