b细胞抗原在中枢神经系统自身免疫中的表现

IF 5.8 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-08-25 DOI:10.1016/j.coi.2025.102647

Carson E Moseley , Joseph J Sabatino Jr , Scott S Zamvil

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引用次数: 0

摘要

抗cd20单克隆抗体在多发性硬化症（MS）中的成功临床试验最初强调了B细胞在中枢神经系统（CNS）自身免疫中的作用。MS以及水通道蛋白4 (AQP4)-IgG+视神经脊髓炎（NMO）和髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）的研究扩大了我们对B细胞在多种中枢神经系统自身免疫性疾病中的作用的认识。B细胞在CNS自身免疫的启动和传播中具有多种功能，这些功能超出了自身抗体的产生，包括通过B细胞抗原呈递与T细胞的双向相互作用。更深入地了解B细胞和T细胞在MS、NMO和MOGAD中的合作，将有助于开发更有效的治疗中枢神经系统自身免疫性疾病的方法。

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B-cell antigen presentation in central nervous system autoimmunity

The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG⁺ neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) has expanded our appreciation of the contribution of B cells in multiple CNS autoimmune diseases. B cells have multiple functions in the initiation and propagation of CNS autoimmunity that extend beyond autoantibody production, including bidirectional interactions with T cells via B-cell antigen presentation. A deeper understanding of the cooperation between B cells and T cells in MS, NMO, and MOGAD should permit the development of more effective therapies across CNS autoimmune disorders.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.