Green Synthesis of Thiazinoquinolines and Evaluation of Antimicrobial and Antioxidant Activity Employing ZnO/CuO@GO Organometallic Nanocatalyst

This study effectively synthesized thiazinoquinolines, a new type of fused heterocyclic compounds, using a multicomponent process with high efficiency. The procedure employed naphthylamine, 2-arylidenemalononitrile, and isothiocyanates in an aqueous solution at ambient temperature, utilizing ZnO/CuO@GO as a recyclable catalyst. Because of having an NH group in the synthesized compounds, we investigate the antioxidant property of some synthesized thiazinoquinoline by diphenyl-picrylhydrazine (DPPH) radical trapping and the power of the ferric reduction experiment. Also, employing Gram-positive and Gram-negative bacteria in the disk diffusion procedure confirmed the antimicrobial effect of some thiazinoquinoline derivatives. The results showed that synthesized compounds prevented bacterial growth. The synthesis of fused thiazinoquinolines demonstrated several advantageous properties, including rapid reactions, elevated yields of the final product, and straightforward separation of the catalyst and product from the reaction mixture.