猪肌腱替代人半腱肌腱的生物力学研究

IF 1.4 3区 医学 Q4 ENGINEERING, BIOMEDICAL
Salim Youssef , Benjamin Fischer , Garen-Ohan Gregorian , Toni Wendler , Philipp Rolzhäuser , Ahmad Hamedy , Pierre Hepp , Stefan Schleifenbaum , Peter Melcher , Yasmin Youssef , Jan Theopold
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引用次数: 0

摘要

在生物力学研究中,猪肌腱经常被用作人类半腱肌腱的替代品,但它们的可比性仍未被探索。方法对猪不同肌腱(前肢伸肌(n = 10)、前肢屈肌(n = 10)、后肢伸肌(n = 10)和后肢屈肌(n = 10))与人半腱肌腱(n = 13)的形态和生物力学特性进行了评价和比较。测量肌腱长度和截面积,采用单轴试验测定最大载荷、抗拉强度、刚度和弹性模量。采用Kruskal-Wallis检验和Dunn事后检验进行统计分析。发现人体半腱肌腱(26.59 cm, 18.98 mm2)的抗拉强度最高,为38.64 MPa,弹性模量为518.27 MPa。猪前腿伸肌的横截面积为14.99 mm2,抗拉强度为32.26 MPa,弹性模量为550.96 MPa,但较短(23.08 cm)。后屈肢的长度(25.81 cm)和弹性模量(610.19 MPa)相似,但抗拉强度(28.13 MPa)较低,横截面积(71.91 mm2)较大。后腿伸肌腱较短(22.62 cm),横截面积较小(11.20 mm2),但拉伸强度(38.82 MPa)和弹性模量(668.83 MPa)与人类肌腱相似。前腿屈肌最短(17.07 cm),横截面积最大(112.74 mm2),抗拉强度最低(18.82 MPa),弹性模量最低(155.70 MPa)。尽管在形态上存在差异,但肌腱的材料特性基本一致。由于前肢伸肌具有相似的材料和形态特征,因此被认为是最合适的半腱动物替代品。由于形态不同,前腿屈肌腱最不适合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Porcine tendons as surrogates for human semitendinosus tendons – A biomechanical study

Background

Porcine tendons are frequently used as surrogates for human semitendinosus tendons in biomechanical studies, yet their comparability remains unexplored.

Methods

This study evaluates and compares the morphological and biomechanical properties of different porcine tendons (foreleg-extensors (n = 10), foreleg-flexors (n = 10), hindleg-extensors (n = 10) and hindleg-flexors (n = 10)) with those of human semitendinosus tendons (n = 13). Tendon length and cross-sectional area were measured, and maximum load, tensile strength, stiffness, and elastic modulus were determined using uniaxial testing. Statistical analysis was performed using the Kruskal-Wallis test followed by Dunn's post hoc test.

Findings

Human semitendinosus tendons (26.59 cm, 18.98 mm2) exhibited the highest tensile strength (38.64 MPa) and an elastic modulus of 518.27 MPa. Porcine foreleg-extensors had comparable cross-sectional area (14.99 mm2), tensile strength (32.26 MPa), and elastic modulus (550.96 MPa) but were shorter (23.08 cm). Hindleg-flexors showed a similar length (25.81 cm) and elastic modulus (610.19 MPa) but lower tensile strength (28.13 MPa) and a substantially larger cross-sectional area (71.91 mm2). Hindleg-extensors were shorter (22.62 cm) with smaller cross-sectional area (11.20 mm2) but exhibited tensile strength (38.82 MPa) and elastic modulus (668.83 MPa) similar to those of the human tendons. Foreleg-flexors were shortest (17.07 cm), with the largest cross-sectional area (112.74 mm2), lowest tensile strength (18.82 MPa), and elastic modulus (155.70 MPa).

Interpretation

Despite differences in morphology, the material properties of tendons were largely consistent. Foreleg-extensors were identified as the most suitable semitendinosus surrogates due to their comparable material and morphological properties. Due to their distinct morphology, foreleg-flexors tendons are least suitable.
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来源期刊
Clinical Biomechanics
Clinical Biomechanics 医学-工程:生物医学
CiteScore
3.30
自引率
5.60%
发文量
189
审稿时长
12.3 weeks
期刊介绍: Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.
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