生物医学用掺钕羟基磷灰石纳米颗粒的结构和功能特性

Q1 Immunology and Microbiology

Biotechnology Reports Pub Date : 2025-08-15 DOI:10.1016/j.btre.2025.e00916

K.Sai Manogna , K. Kusuma , G.Rajasekhara Reddy , B.Deva Prasad Raju , N.John Sushma

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引用次数: 0

摘要

合成了钕（Nd³）掺杂羟基磷灰石纳米粒子（Han: Nd³+ NPs）并对其进行了系统表征，以评估其在生物医学应用中的结构和功能特性。x射线衍射（XRD）证实了掺杂后的晶体相保留，而x射线光电子能谱（XPS）则证实了Nd³+离子的成功掺杂。掺杂改变了光学和电子特性，潜在地增强了生物活性和成像能力。MCF7和4T1乳腺癌细胞系的初步细胞毒性评估显示剂量依赖性，IC50值分别为36.13µg/mL和64.38µg/mL。该研究得出结论，Han: Nd³+ NPs作为细胞毒性反应和结构稳定性的多功能平台，具有未来在成像和靶向乳腺癌治疗中的应用潜力。

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Structural and functional properties of neodymium-doped hydroxyapatite nanoparticles for biomedical applications

Neodymium (Nd³⁺) doped hydroxyapatite nanoparticles (Han: Nd³⁺ NPs) were synthesized and systematically characterized to evaluate their structural and functional properties for biomedical applications. X-ray diffraction (XRD) confirmed the crystalline phase retention post-doping, while x-ray photoelectron spectroscopy (XPS) revealed the successful incorporation of Nd³⁺ ions. The doping altered the optical and electronic properties, potentially enhancing bioactivity and imaging capabilities. Preliminary cytotoxicity assessments on MCF7 and 4T1 breast cancer cell lines indicated dose-dependent effects, with IC50 values of 36.13 µg/mL and 64.38 µg/mL, respectively. The study concludes that Han: Nd³⁺ NPs offer promise as multifunctional platforms for cytotoxic response and structural stability, with potential for future application in imaging and targeted breast cancer therapy.

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来源期刊

Biotechnology Reports Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

15.80

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Biotechnology Reports covers all aspects of Biotechnology particularly those reports that are useful and informative and that will be of value to other researchers in related fields. Biotechnology Reports loves ground breaking science, but will also accept good science that can be of use to the biotechnology community. The journal maintains a high quality peer review where submissions are considered on the basis of scientific validity and technical quality. Acceptable paper types are research articles (short or full communications), methods, mini-reviews, and commentaries in the following areas: Healthcare and pharmaceutical biotechnology Agricultural and food biotechnology Environmental biotechnology Molecular biology, cell and tissue engineering and synthetic biology Industrial biotechnology, biofuels and bioenergy Nanobiotechnology Bioinformatics & systems biology New processes and products in biotechnology, bioprocess engineering.