Michał Gebuza , Julia Górczyńska , Wiktoria Paczos , Szymon Pieczara , Katarzyna Rekiel , Piotr Urbanowicz , Marek Kulbacki , Vitalij Novickij , Julita Kulbacka
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Exploring the mechanical and electrical properties of cancer cells for improved diagnosis and treatment
Over the past decade, there has been growing interest in the mechanical and electrical properties of cancer cells and their potential for improved diagnosis and treatment. Cancer cells exhibit unique mechanical and electrical properties, including altered stiffness, adhesion, charge, and shape, which distinguish them from normal cells. Researchers are exploring ways to use these properties to develop new diagnostic tools and therapeutic approaches that selectively target cancer cells while minimizing harm to healthy tissue. Recent advancements in machine learning (ML) have enhanced the analysis of cancer cell behavior, enabling more accurate identification based on electrical and mechanical “biomarkers” and offering the potential for early diagnosis and personalized treatment strategies. In this review, we will examine the most recent research on the mechanical and electrical properties of cancer cells and discuss their potential implications for enhancing the diagnosis and treatment of cancer.
期刊介绍:
Archives of Biochemistry and Biophysics publishes quality original articles and reviews in the developing areas of biochemistry and biophysics.
Research Areas Include:
• Enzyme and protein structure, function, regulation. Folding, turnover, and post-translational processing
• Biological oxidations, free radical reactions, redox signaling, oxygenases, P450 reactions
• Signal transduction, receptors, membrane transport, intracellular signals. Cellular and integrated metabolism.