{"title":"利用短横向弛豫时间分量(ViSTa)直接可视化的三维高效髓鞘加权成像","authors":"Se-Hong Oh, Gawon Lee, Jongho Lee","doi":"10.1002/hbm.70307","DOIUrl":null,"url":null,"abstract":"<p>Measuring myelin concentration in the brain has important implications in basic science and clinical practice. In MRI, myelin water imaging (MWI) has been suggested as a surrogate biomarker that provides high sensitivity and specificity for myelin. However, multi-exponential fitting is ill-conditioned, and it is sensitive to noise and artifacts, particularly in vivo. To overcome the ill-conditioned fitting problem, the two-dimensional ViSTa myelin-weighted imaging technique was proposed, and it provides a substantially improved myelin-weighted image. However, it is based on a two-dimensional single-slice acquisition scheme, and it is a limitation. In this study, a whole brain-covered 3D ViSTa sequence, based on a 3D segmented echo planar imaging (EPI) sequence with a pair of slice selective inversion RF pulses, was proposed. To investigate the 3D ViSTa myelin weighted image, the distribution of myelin content in the white matter of the brain was measured using both conventional MWI and ViSTa MWI. The proposed 3D ViSTa method achieves a whole brain-covered (FOV = 240 × 240 × 128 mm<sup>3</sup>) myelin water-weighted image in less than 8 min (1.5 × 1.5 × 4 mm<sup>3</sup>) and does not require heavy post-processing. Pseudo-quantification (apparent MWF) can be provided by normalizing the ViSTa image with a PD-weighted image. The voxel-wise correlation between the conventional MWI and the 3D ViSTa yielded a mean correlation coefficient of 0.74 ± 0.03 (mean ± standard deviation of the five subjects), demonstrating a high spatial similarity in myelin-weighted contrast between the two maps. The proposed 3D ViSTa with pseudo-quantification may be useful in clinical applications when absolute quantification is not necessary.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 12","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70307","citationCount":"0","resultStr":"{\"title\":\"Three-Dimensional Efficient Myelin-Weighted Imaging Utilizing Direct Visualization of Short Transverse Relaxation Time Component (ViSTa)\",\"authors\":\"Se-Hong Oh, Gawon Lee, Jongho Lee\",\"doi\":\"10.1002/hbm.70307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Measuring myelin concentration in the brain has important implications in basic science and clinical practice. In MRI, myelin water imaging (MWI) has been suggested as a surrogate biomarker that provides high sensitivity and specificity for myelin. However, multi-exponential fitting is ill-conditioned, and it is sensitive to noise and artifacts, particularly in vivo. To overcome the ill-conditioned fitting problem, the two-dimensional ViSTa myelin-weighted imaging technique was proposed, and it provides a substantially improved myelin-weighted image. However, it is based on a two-dimensional single-slice acquisition scheme, and it is a limitation. In this study, a whole brain-covered 3D ViSTa sequence, based on a 3D segmented echo planar imaging (EPI) sequence with a pair of slice selective inversion RF pulses, was proposed. To investigate the 3D ViSTa myelin weighted image, the distribution of myelin content in the white matter of the brain was measured using both conventional MWI and ViSTa MWI. The proposed 3D ViSTa method achieves a whole brain-covered (FOV = 240 × 240 × 128 mm<sup>3</sup>) myelin water-weighted image in less than 8 min (1.5 × 1.5 × 4 mm<sup>3</sup>) and does not require heavy post-processing. Pseudo-quantification (apparent MWF) can be provided by normalizing the ViSTa image with a PD-weighted image. The voxel-wise correlation between the conventional MWI and the 3D ViSTa yielded a mean correlation coefficient of 0.74 ± 0.03 (mean ± standard deviation of the five subjects), demonstrating a high spatial similarity in myelin-weighted contrast between the two maps. The proposed 3D ViSTa with pseudo-quantification may be useful in clinical applications when absolute quantification is not necessary.</p>\",\"PeriodicalId\":13019,\"journal\":{\"name\":\"Human Brain Mapping\",\"volume\":\"46 12\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70307\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Brain Mapping\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hbm.70307\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROIMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Brain Mapping","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hbm.70307","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROIMAGING","Score":null,"Total":0}
Three-Dimensional Efficient Myelin-Weighted Imaging Utilizing Direct Visualization of Short Transverse Relaxation Time Component (ViSTa)
Measuring myelin concentration in the brain has important implications in basic science and clinical practice. In MRI, myelin water imaging (MWI) has been suggested as a surrogate biomarker that provides high sensitivity and specificity for myelin. However, multi-exponential fitting is ill-conditioned, and it is sensitive to noise and artifacts, particularly in vivo. To overcome the ill-conditioned fitting problem, the two-dimensional ViSTa myelin-weighted imaging technique was proposed, and it provides a substantially improved myelin-weighted image. However, it is based on a two-dimensional single-slice acquisition scheme, and it is a limitation. In this study, a whole brain-covered 3D ViSTa sequence, based on a 3D segmented echo planar imaging (EPI) sequence with a pair of slice selective inversion RF pulses, was proposed. To investigate the 3D ViSTa myelin weighted image, the distribution of myelin content in the white matter of the brain was measured using both conventional MWI and ViSTa MWI. The proposed 3D ViSTa method achieves a whole brain-covered (FOV = 240 × 240 × 128 mm3) myelin water-weighted image in less than 8 min (1.5 × 1.5 × 4 mm3) and does not require heavy post-processing. Pseudo-quantification (apparent MWF) can be provided by normalizing the ViSTa image with a PD-weighted image. The voxel-wise correlation between the conventional MWI and the 3D ViSTa yielded a mean correlation coefficient of 0.74 ± 0.03 (mean ± standard deviation of the five subjects), demonstrating a high spatial similarity in myelin-weighted contrast between the two maps. The proposed 3D ViSTa with pseudo-quantification may be useful in clinical applications when absolute quantification is not necessary.
期刊介绍:
Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged.
Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.