古老的双手性蛋白质违背了分子手性的规则

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2025-08-22 DOI:10.1007/s12039-025-02419-1

Dibyendu Das

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引用次数: 0

摘要

最近，地球生命科学研究所的利亚姆·朗戈和他的同事发表在《安吉万特化学》杂志上的一项研究报告称，他们发现了一种古老的螺旋-发针-螺旋蛋白基序，能够以左手和右手的形式发挥作用，从而挑战了生物分子相互作用严格依赖于同手性的概念。这种相当罕见的“双灵巧”特性表明，这种基序可能是前卢卡时代的分子遗迹，当时镜像生命形式共存，并为生物物质中分子不对称的起源和进化提供了新的见解。图形摘要“螺旋-发夹-螺旋”基序允许一个简单的肽结合到DNA和它的镜像。来源：Liam M S Longo

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ancient ambidextrous protein defies the rule of molecular handedness

A recent study by Liam Longo and co-workers at the Earth-Life Science Institute, published in Angewandte Chemie, reports the discovery of an ancient helix-hairpin-helix protein motif capable of functioning in both left- and right-handed forms, thus challenging the concept that biomolecular interactions are strictly dependent on homochirality. This rather rare “ambidextrous” property suggests that such motifs may be molecular relics from a pre-LUCA era when mirror-image life forms coexisted, and offers new insights into the origins and evolution of molecular asymmetry seen in living matter.

Graphical abstract

The ‘helix-hairpin-helix’ motif allows the binding of a simple peptide to both DNA and its mirror image. Credit: Liam M S Longo.

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.