Felipe Carniel , Gustavo Willian Pandolfo , Paulo E. Ferian , Julieta Volpato , Maysa Garlet Nunes Xavier , Mariângela Lovatel , Marília Luciani , Eloiza Zoboli , João Fabio Soares , Renata Assis Casagrande
{"title":"巴西南部自然感染犬体内的重要Rangelia:疾病分为急性期和亚急性期的临床分类","authors":"Felipe Carniel , Gustavo Willian Pandolfo , Paulo E. Ferian , Julieta Volpato , Maysa Garlet Nunes Xavier , Mariângela Lovatel , Marília Luciani , Eloiza Zoboli , João Fabio Soares , Renata Assis Casagrande","doi":"10.1016/j.vprsr.2025.101333","DOIUrl":null,"url":null,"abstract":"<div><div>Canine rangeliosis, caused by <em>Rangelia vitalii</em>, is an extravascular hemolytic disease. This study aimed to establish a clinical classification of the disease into acute and subacute phases and to describe the clinical, hematological, and pathological findings in naturally infected dogs. Eighteen dogs were included and submitted a complete blood count, serum biochemistry, ear margin blood smear, abdominal ultrasonography, polymerase chain reaction for <em>R. vitalii</em> and <em>Babesia</em> spp., and three dogs were necropsied. All animals were positive for <em>R. vitalii</em> and negative for <em>Babesia</em> spp. The most consistent findings in the acute phase included thrombocytopenia, macrocytosis, Howell-Jolly bodies, coarse hypoechoic splenomegaly, hyperthermia, and tachycardia. In the subacute phase, findings included moderate thrombocytopenia, macrothrombocytes, anisocytosis, and polychromasia, anemia, coarse hypoechoic splenomegaly, hypoproteinemia and hypoalbuminemia, increased urinary gamma-glutamyl transferase levels, lethargy, and anorexia. Thrombocytopenia and splenomegaly were the most frequent alterations, present in all cases. In blood smears, the protozoan was in its free form in 61.1 % of cases. The pathological findings were characteristic of extravascular hemolytic disease, with the most severe tissue parasitism was observed in the intestine, heart, pancreas, and bladder. This study to describe the clinical features of rangeliosis, emphasizing a clinical classification of the disease into to acute and subacute phases.</div></div>","PeriodicalId":23600,"journal":{"name":"Veterinary parasitology, regional studies and reports","volume":"64 ","pages":"Article 101333"},"PeriodicalIF":1.4000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rangelia vitalii in naturally infected dogs in southern Brazil: clinical classification of the disease into acute and subacute phases\",\"authors\":\"Felipe Carniel , Gustavo Willian Pandolfo , Paulo E. Ferian , Julieta Volpato , Maysa Garlet Nunes Xavier , Mariângela Lovatel , Marília Luciani , Eloiza Zoboli , João Fabio Soares , Renata Assis Casagrande\",\"doi\":\"10.1016/j.vprsr.2025.101333\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Canine rangeliosis, caused by <em>Rangelia vitalii</em>, is an extravascular hemolytic disease. This study aimed to establish a clinical classification of the disease into acute and subacute phases and to describe the clinical, hematological, and pathological findings in naturally infected dogs. Eighteen dogs were included and submitted a complete blood count, serum biochemistry, ear margin blood smear, abdominal ultrasonography, polymerase chain reaction for <em>R. vitalii</em> and <em>Babesia</em> spp., and three dogs were necropsied. All animals were positive for <em>R. vitalii</em> and negative for <em>Babesia</em> spp. The most consistent findings in the acute phase included thrombocytopenia, macrocytosis, Howell-Jolly bodies, coarse hypoechoic splenomegaly, hyperthermia, and tachycardia. In the subacute phase, findings included moderate thrombocytopenia, macrothrombocytes, anisocytosis, and polychromasia, anemia, coarse hypoechoic splenomegaly, hypoproteinemia and hypoalbuminemia, increased urinary gamma-glutamyl transferase levels, lethargy, and anorexia. Thrombocytopenia and splenomegaly were the most frequent alterations, present in all cases. In blood smears, the protozoan was in its free form in 61.1 % of cases. The pathological findings were characteristic of extravascular hemolytic disease, with the most severe tissue parasitism was observed in the intestine, heart, pancreas, and bladder. This study to describe the clinical features of rangeliosis, emphasizing a clinical classification of the disease into to acute and subacute phases.</div></div>\",\"PeriodicalId\":23600,\"journal\":{\"name\":\"Veterinary parasitology, regional studies and reports\",\"volume\":\"64 \",\"pages\":\"Article 101333\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary parasitology, regional studies and reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405939025001418\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary parasitology, regional studies and reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405939025001418","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Rangelia vitalii in naturally infected dogs in southern Brazil: clinical classification of the disease into acute and subacute phases
Canine rangeliosis, caused by Rangelia vitalii, is an extravascular hemolytic disease. This study aimed to establish a clinical classification of the disease into acute and subacute phases and to describe the clinical, hematological, and pathological findings in naturally infected dogs. Eighteen dogs were included and submitted a complete blood count, serum biochemistry, ear margin blood smear, abdominal ultrasonography, polymerase chain reaction for R. vitalii and Babesia spp., and three dogs were necropsied. All animals were positive for R. vitalii and negative for Babesia spp. The most consistent findings in the acute phase included thrombocytopenia, macrocytosis, Howell-Jolly bodies, coarse hypoechoic splenomegaly, hyperthermia, and tachycardia. In the subacute phase, findings included moderate thrombocytopenia, macrothrombocytes, anisocytosis, and polychromasia, anemia, coarse hypoechoic splenomegaly, hypoproteinemia and hypoalbuminemia, increased urinary gamma-glutamyl transferase levels, lethargy, and anorexia. Thrombocytopenia and splenomegaly were the most frequent alterations, present in all cases. In blood smears, the protozoan was in its free form in 61.1 % of cases. The pathological findings were characteristic of extravascular hemolytic disease, with the most severe tissue parasitism was observed in the intestine, heart, pancreas, and bladder. This study to describe the clinical features of rangeliosis, emphasizing a clinical classification of the disease into to acute and subacute phases.
期刊介绍:
Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).