{"title":"肉毒杆菌毒素A治疗小儿下肢痉挛的有效性和安全性：一项前瞻性、观察性、多中心的IV期研究。","authors":"","doi":"10.1111/dmcn.16487","DOIUrl":null,"url":null,"abstract":"<p>Damage to the central nervous system can cause an abnormal, involuntary muscle tightness in the legs known as lower limb spasticity. In children, the most common causes of this permanent stiffening of the muscles are cerebral palsy, stroke, brain injury, and spinal cord injury.</p><p>AbobotulinumtoxinA (aboBoNT-A) is often used to reduce the muscle tightness and improve leg function and/or quality of life. Because muscle tightness can vary from individual to individual, treatment should be tailored to patients according to their goals. The Goal Attainment Scaling (GAS) is a method that allows patients and healthcare professionals to set specific goals together, focusing on improving the patient's function and participation in daily life activities. In this study, children and adolescents with lower limb muscle tightness were treated with aboBoNT-A up to 10 times over a period of up to 30 months.</p>","PeriodicalId":50587,"journal":{"name":"Developmental Medicine and Child Neurology","volume":"67 10","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16487","citationCount":"0","resultStr":"{\"title\":\"Effectiveness and safety of abobotulinumtoxinA in pediatric lower limb spasticity: A phase IV, prospective, observational, multicenter study\",\"authors\":\"\",\"doi\":\"10.1111/dmcn.16487\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Damage to the central nervous system can cause an abnormal, involuntary muscle tightness in the legs known as lower limb spasticity. In children, the most common causes of this permanent stiffening of the muscles are cerebral palsy, stroke, brain injury, and spinal cord injury.</p><p>AbobotulinumtoxinA (aboBoNT-A) is often used to reduce the muscle tightness and improve leg function and/or quality of life. Because muscle tightness can vary from individual to individual, treatment should be tailored to patients according to their goals. The Goal Attainment Scaling (GAS) is a method that allows patients and healthcare professionals to set specific goals together, focusing on improving the patient's function and participation in daily life activities. In this study, children and adolescents with lower limb muscle tightness were treated with aboBoNT-A up to 10 times over a period of up to 30 months.</p>\",\"PeriodicalId\":50587,\"journal\":{\"name\":\"Developmental Medicine and Child Neurology\",\"volume\":\"67 10\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dmcn.16487\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental Medicine and Child Neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16487\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Medicine and Child Neurology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16487","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Effectiveness and safety of abobotulinumtoxinA in pediatric lower limb spasticity: A phase IV, prospective, observational, multicenter study
Damage to the central nervous system can cause an abnormal, involuntary muscle tightness in the legs known as lower limb spasticity. In children, the most common causes of this permanent stiffening of the muscles are cerebral palsy, stroke, brain injury, and spinal cord injury.
AbobotulinumtoxinA (aboBoNT-A) is often used to reduce the muscle tightness and improve leg function and/or quality of life. Because muscle tightness can vary from individual to individual, treatment should be tailored to patients according to their goals. The Goal Attainment Scaling (GAS) is a method that allows patients and healthcare professionals to set specific goals together, focusing on improving the patient's function and participation in daily life activities. In this study, children and adolescents with lower limb muscle tightness were treated with aboBoNT-A up to 10 times over a period of up to 30 months.
期刊介绍：
Wiley-Blackwell is pleased to publish Developmental Medicine & Child Neurology (DMCN), a Mac Keith Press publication and official journal of the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and the British Paediatric Neurology Association (BPNA).
For over 50 years, DMCN has defined the field of paediatric neurology and neurodisability and is one of the world’s leading journals in the whole field of paediatrics. DMCN disseminates a range of information worldwide to improve the lives of disabled children and their families. The high quality of published articles is maintained by expert review, including independent statistical assessment, before acceptance.
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