癌症生物学中的乳酸化:开启研究和治疗的新途径。

IF 24.9 1区 医学 Q1 ONCOLOGY
Xiaoyu Hou, Zhenya Hong, Huimin Zen, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han
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引用次数: 0

摘要

乳酸酰化是一种新发现的翻译后修饰,通过整合表观遗传和非表观遗传机制在癌症生物学中起着多方面的作用。本文综述了乳酸化的最新研究进展,包括其在表观遗传调控中的功能及其对细胞过程的广泛影响。乳酸作为一种代谢副产物,不仅是肿瘤细胞的能量来源,而且是驱动各种致癌过程的信号分子。乳酸化促进癌症代谢重编程,使肿瘤细胞适应缺氧和营养缺乏的微环境。此外,乳酸化介导肿瘤微环境中的免疫抑制,促进免疫逃避和治疗抵抗。本文将进一步探讨靶向乳酸化的临床潜力,为癌症研究和治疗的创新提供新的途径。这些发现强调了乳酸化在癌症进展中的关键作用及其作为潜在治疗靶点的重要价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lactylation in cancer biology: Unlocking new avenues for research and therapy.

Lactylation, a newly identified post-translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non-epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes. Lactate, as a metabolic byproduct, not only serves as an energy source for tumor cells but also acts as a signaling molecule driving various oncogenic processes. Lactylation facilitates cancer metabolic reprogramming, enabling tumor cells to adapt to hypoxic and nutrient-deprived microenvironments. Moreover, lactylation mediates immune suppression in the tumor microenvironment, promoting immune evasion and therapy resistance. This review further explores the clinical potential of targeting lactylation, offering new avenues for innovation in cancer research and treatment. These findings highlight the pivotal role of lactylation in cancer progression and its significant value as a potential therapeutic target.

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来源期刊
Cancer Communications
Cancer Communications Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
25.50
自引率
4.30%
发文量
153
审稿时长
4 weeks
期刊介绍: Cancer Communications is an open access, peer-reviewed online journal that encompasses basic, clinical, and translational cancer research. The journal welcomes submissions concerning clinical trials, epidemiology, molecular and cellular biology, and genetics.
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