肌少症的发病机制、诊断方法和当前营养支持策略。

IF 2.6 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Yafei Zhang, Kai Zhang, Yi Xue, Yuqi Wang, Heng Quan, Xiaoya Lin, Yao Lu
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引用次数: 0

摘要

肌少症是一种特殊的疾病,常见于老年人和消费性疾病患者。肌肉减少症会导致力量和运动能力严重下降,甚至导致长时间卧床休息。营养支持是缓解肌肉减少症的一种新兴方法,目前是临床治疗肌肉减少症的金标准。然而,复杂的营养成分可能会影响治疗效果。本文首先介绍肌肉减少症的发病机制。然后,详细介绍了肌肉减少症的诊断方法,包括握力、椅架测试、双能x线吸收仪、生物电阻抗分析、步态速度、平衡测试和生物标志物。然后,阐述了营养支持(包括蛋白质的数量和质量、生物活性肽、氨基酸及其代谢物、抗氧化/抗炎营养素、维生素和矿物质、微生物组靶向干预、代谢物衍生分子和中草药)在缓解肌肉减少症方面的最新进展。本文综述有助于了解肌少症的发病机制以及诊断和营养支持在缓解肌少症中的重要性,从而促进肌少症治疗的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathogenesis, Diagnosis Method, and Current Nutritional Support Strategy for Sarcopenia.

Sarcopenia is a specific disease that commonly occurs in the elderly and patients with consumptive diseases. Sarcopenia can cause a severe decline in strength and movement, and even lead to prolonged bed rest. Nutritional support is an emerging approach to mitigate sarcopenia and is currently the gold standard for clinical management of sarcopenia. However, complex nutritional composition may affect the effect of treatment. Herein, the pathogenesis of sarcopenia is first introduced. Then, the diagnostic methods of sarcopenia are described in detail, including grip strength, chair stand test, dual-energy X-ray Absorptiometry, bioelectrical impedance analysis, gait speed, balance tests, and biomarkers. Then, the latest progress of the nutritional support (including protein quantity and quality, bioactive peptides, amino acids and their metabolites, antioxidant/ anti-inflammatory nutrients, vitamins and minerals, microbiome-targeted interventions, metabolite-derived molecules, and Chinese herbal medicine) on the mitigation of sarcopenia is elaborated. This review may contribute to the understanding of the mechanism and importance of diagnosis and nutritional support in alleviating sarcopenia, so as to promote the development of sarcopenia treatment.

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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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