封面：网格蛋白末端结构域- amphiphysin蛋白-蛋白相互作用的抑制。探测Pitstop 2芳香部分（ChemMedChem 16/2025）

IF 3.4 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-08-21 DOI:10.1002/cmdc.70019

Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey

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引用次数: 0

摘要

这张图显示了网格蛋白n端结构域的晶体结构，已知的结合位点被着色。位点1用黄色表示，扩展图显示了Pitstop 2类似物与结合位点Pitstop 2的预测结合的程式化图像。背景显示了文章中描述的各种颜色的Pitstop 2类似物的选择。更多细节可以在研究文章10.1002/cmdc中找到。202500321由Adam McCluskey及其同事编写。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)

查看原文本刊更多论文

Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)

This image shows the crystal structure of the N-terminal domain of clathrin with the known binding sites colored. Site 1 is colored in yellow, and an expansion shows a stylized image of the predicted binding of a Pitstop 2 analogue compared to Pitstop 2 in binding site. The background shows a selection of the Pitstop 2 analogues described in the article in various colors. More details can be found in research article 10.1002/cmdc.202500321 by Adam McCluskey and co-workers.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.