Shaoqing Chen, Caiqin Liang, Pengyin Li, Chun Liu, Xierong Zeng, Xinbo Xiong, Xinye Ni
{"title":"聚多巴胺/聚乙烯醇/氧化石墨烯过渡层在水热电沉积/水热处理制备的Cf/C复合材料上增强HA涂层的粘接性能","authors":"Shaoqing Chen, Caiqin Liang, Pengyin Li, Chun Liu, Xierong Zeng, Xinbo Xiong, Xinye Ni","doi":"10.1007/s10856-025-06922-2","DOIUrl":null,"url":null,"abstract":"<div><p>Hydroxyapatite (HA) coatings on carbon fiber-reinforced carbon (C<sub>f</sub>/C) composites hold promise for orthopedic implants. However, the interface between HA and C<sub>f</sub>/C is prone to delamination, limiting its application. To address this, a polydopamine (PDA)-polyvinyl alcohol (PVA)-graphene oxide (GO) transition layer was introduced to reinforce and toughen HA coatings on C<sub>f</sub>/C composites (PDA-PVA-GO/C<sub>f</sub>/C) via hydrothermal electro-deposition/post-hydrothermal treatment. For comparison, the PDA and PDA/PVA transition layers were also prepared on C<sub>f</sub>/C, designated as PDA/C<sub>f</sub>/C and PDA-PVA/C<sub>f</sub>/C, respectively. The precursor and transformed coatings obtained were monetite and HA. XRD analyses revealed that PDA and PVA infiltrated the monetite lattice without affecting the HA lattice parameters. Remarkably, scratch tests demonstrated that the HA/PVD-PVA-GO coating on C<sub>f</sub>/C exhibited a dense configuration and compact interfacial structure, achieving a maximum critical load of 51.5 N, surpassing other reported electrochemically prepared HA coatings. Moreover, scratch tests indicated a more homogeneous scratch pattern with no sudden delamination of the coating from the matrix. In vitro assessments revealed that all HA coatings with the transition layer exhibited enhanced bioactivity and cell compatibility compared with HA alone. In particular, PDA/PVA/GO-C<sub>f</sub>/C exhibited the best superior efficacy in promoting the proliferation of mouse embryonic osteoblast precursor (MC3T3-E1) cells and significantly increased Alkaline phosphatase (ALP) production in rat bone marrow mesenchymal stem cells (BMSCs). These findings underscore the potential of PDA-PVA-GO/C<sub>f</sub>/C as a promising biomaterial for bone regeneration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"36 1","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-025-06922-2.pdf","citationCount":"0","resultStr":"{\"title\":\"Polydopamine/polyvinyl alcohol/graphene oxide transition layer for enhancing adhesive performance of HA coating on Cf/C composites prepared by hydrothermal electrodeposition/hydrothermal treatment\",\"authors\":\"Shaoqing Chen, Caiqin Liang, Pengyin Li, Chun Liu, Xierong Zeng, Xinbo Xiong, Xinye Ni\",\"doi\":\"10.1007/s10856-025-06922-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Hydroxyapatite (HA) coatings on carbon fiber-reinforced carbon (C<sub>f</sub>/C) composites hold promise for orthopedic implants. However, the interface between HA and C<sub>f</sub>/C is prone to delamination, limiting its application. To address this, a polydopamine (PDA)-polyvinyl alcohol (PVA)-graphene oxide (GO) transition layer was introduced to reinforce and toughen HA coatings on C<sub>f</sub>/C composites (PDA-PVA-GO/C<sub>f</sub>/C) via hydrothermal electro-deposition/post-hydrothermal treatment. For comparison, the PDA and PDA/PVA transition layers were also prepared on C<sub>f</sub>/C, designated as PDA/C<sub>f</sub>/C and PDA-PVA/C<sub>f</sub>/C, respectively. The precursor and transformed coatings obtained were monetite and HA. XRD analyses revealed that PDA and PVA infiltrated the monetite lattice without affecting the HA lattice parameters. Remarkably, scratch tests demonstrated that the HA/PVD-PVA-GO coating on C<sub>f</sub>/C exhibited a dense configuration and compact interfacial structure, achieving a maximum critical load of 51.5 N, surpassing other reported electrochemically prepared HA coatings. Moreover, scratch tests indicated a more homogeneous scratch pattern with no sudden delamination of the coating from the matrix. In vitro assessments revealed that all HA coatings with the transition layer exhibited enhanced bioactivity and cell compatibility compared with HA alone. In particular, PDA/PVA/GO-C<sub>f</sub>/C exhibited the best superior efficacy in promoting the proliferation of mouse embryonic osteoblast precursor (MC3T3-E1) cells and significantly increased Alkaline phosphatase (ALP) production in rat bone marrow mesenchymal stem cells (BMSCs). 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Polydopamine/polyvinyl alcohol/graphene oxide transition layer for enhancing adhesive performance of HA coating on Cf/C composites prepared by hydrothermal electrodeposition/hydrothermal treatment
Hydroxyapatite (HA) coatings on carbon fiber-reinforced carbon (Cf/C) composites hold promise for orthopedic implants. However, the interface between HA and Cf/C is prone to delamination, limiting its application. To address this, a polydopamine (PDA)-polyvinyl alcohol (PVA)-graphene oxide (GO) transition layer was introduced to reinforce and toughen HA coatings on Cf/C composites (PDA-PVA-GO/Cf/C) via hydrothermal electro-deposition/post-hydrothermal treatment. For comparison, the PDA and PDA/PVA transition layers were also prepared on Cf/C, designated as PDA/Cf/C and PDA-PVA/Cf/C, respectively. The precursor and transformed coatings obtained were monetite and HA. XRD analyses revealed that PDA and PVA infiltrated the monetite lattice without affecting the HA lattice parameters. Remarkably, scratch tests demonstrated that the HA/PVD-PVA-GO coating on Cf/C exhibited a dense configuration and compact interfacial structure, achieving a maximum critical load of 51.5 N, surpassing other reported electrochemically prepared HA coatings. Moreover, scratch tests indicated a more homogeneous scratch pattern with no sudden delamination of the coating from the matrix. In vitro assessments revealed that all HA coatings with the transition layer exhibited enhanced bioactivity and cell compatibility compared with HA alone. In particular, PDA/PVA/GO-Cf/C exhibited the best superior efficacy in promoting the proliferation of mouse embryonic osteoblast precursor (MC3T3-E1) cells and significantly increased Alkaline phosphatase (ALP) production in rat bone marrow mesenchymal stem cells (BMSCs). These findings underscore the potential of PDA-PVA-GO/Cf/C as a promising biomaterial for bone regeneration.
期刊介绍：
The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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