Ramsha Munir, Ameer Fawad Zahoor, Samreen Gul Khan, Syed Makhdoom Hussain, Razia Noreen, Asim Mansha, Freeha Hafeez, Ahmad Irfan, Muhammad Ahmad
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Total Syntheses of Deuterated Drugs: A Comprehensive Review
Deuterium is a safe bioisostere of hydrogen, and its selective labeling has a great prominence in medicinal chemistry for the amelioration of the pharmacokinetic profiles of the drugs. The deuterium-labeled pharmaceutically active compounds have been observed to exhibit broad applications, either as deuterated drugs or as pharmacokinetic probes (biomarkers). The deuterated drugs offer improved bioactivity and metabolic profile in terms of tolerability, efficacy, and reduced toxicity. In this manuscript, the synthetic strategies of various deuterated drugs including antiviral, anticancer, antiarrhythmic, antidiabetic, anticholinergic, antibiotics, antidepressants, and antipyretics have been documented. In addition, this review article also comprises a broad class of miscellaneous drugs i.e., antiasthmatic drugs, antiseptics, topical analgesics, antifibrotic agents, immunosuppressants, and central nervous system (CNS) suppressants. Additionally, the synthesis of several deuterated pharmaceutically active compounds as biomarkers has also been compiled in this review. Leveraging the modern platform of precision deuteration, this review article provides a repertoire of synthetic strategies for the synthesis of several deuterated drugs reported over a period of 2005–2024 (two decades).
期刊介绍：
Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science.
Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community.
In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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