朗格汉斯细胞密度在口腔鳞状细胞癌、唇鳞状细胞癌和口腔潜在恶性疾病中的差异：系统综述和网络荟萃分析

IF 2.1 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-08-14 DOI:10.1016/j.archoralbio.2025.106372

Naiara Alves Marega , Luana Paula Borges da Costa e Silva , Analú Barros de Oliveira , Rafaella Luiza Bergamaschi de Carli , Andreia Bufalino , Elaine Maria Sgavioli Massucato , Túlio Morandin Ferrisse

{"title":"朗格汉斯细胞密度在口腔鳞状细胞癌、唇鳞状细胞癌和口腔潜在恶性疾病中的差异：系统综述和网络荟萃分析","authors":"Naiara Alves Marega , Luana Paula Borges da Costa e Silva , Analú Barros de Oliveira , Rafaella Luiza Bergamaschi de Carli , Andreia Bufalino , Elaine Maria Sgavioli Massucato , Túlio Morandin Ferrisse","doi":"10.1016/j.archoralbio.2025.106372","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>to evaluate whether Langerhans cells (LC) (CD1a+, CD207 +) show quantification differences in oral squamous cell carcinoma (OSCC), lip squamous cell carcinoma (LSCC), and oral potentially malignant disorders (OPMDs), due to previously conflicting results.</div></div><div><h3>Design</h3><div>PubMed, Scopus, Embase, Lilacs, and Web of Science were the databases searched. The protocol was registered in the Open Science Framework (OSF). Rayyan software was used for duplicate removal. Risk of bias was assessed using the Joanna Briggs Institute (JBI) scale for cross-sectional studies. Meta-analyses were conducted using R software (v3.6.3) with the \"NETMETA\" package. Quality of evidence was evaluated using the CINeMA tool. In total, 26 articles were included for qualitative and 14 articles for quantitative analysis</div></div><div><h3>Results</h3><div>Higher CD1a+ and CD207 + LC levels were observed in low-grade OSCC compared to well and moderately differentiated OSCC. In addition, reductions of CD1a+ and CD207 + LC were associated with locoregional metastasis to lymph nodes. Among OPMDs, oral lichen planus (OLP) showed the highest CD1a+ and CD207 + density. Significant reductions in LC counts were noted in oral leukoplakia (OL), oral submucous fibrosis (OSF), and OSCC. In LSCC, CD1a+ LCs were significantly reduced compared to actinic cheilitis (AC). Sampling and statistical biases were identified in 7 and 17 studies respectively.</div></div><div><h3>Conclusion</h3><div>Differences in CD1a+ and CD207 + LC densities among OSCC, LSCC, and OPMDs may cooperate in understanding of their immunopathogenesis and support diagnostic and therapeutic strategies in these conditions. Furthermore, CD1a+ and CD207 + density reduction may have the potential to be used as a biomarker for oral malignant transformation. In general, a high confidence rate was observed for CD207 + LC and a moderate confidence for CD1a+ LC was noted.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"179 ","pages":"Article 106372"},"PeriodicalIF":2.1000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Different densities of Langerhans cells among oral squamous cell carcinoma, lip squamous cell carcinoma and oral potentially malignant disorders: Systematic review and network meta-analysis\",\"authors\":\"Naiara Alves Marega , Luana Paula Borges da Costa e Silva , Analú Barros de Oliveira , Rafaella Luiza Bergamaschi de Carli , Andreia Bufalino , Elaine Maria Sgavioli Massucato , Túlio Morandin Ferrisse\",\"doi\":\"10.1016/j.archoralbio.2025.106372\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>to evaluate whether Langerhans cells (LC) (CD1a+, CD207 +) show quantification differences in oral squamous cell carcinoma (OSCC), lip squamous cell carcinoma (LSCC), and oral potentially malignant disorders (OPMDs), due to previously conflicting results.</div></div><div><h3>Design</h3><div>PubMed, Scopus, Embase, Lilacs, and Web of Science were the databases searched. The protocol was registered in the Open Science Framework (OSF). Rayyan software was used for duplicate removal. Risk of bias was assessed using the Joanna Briggs Institute (JBI) scale for cross-sectional studies. Meta-analyses were conducted using R software (v3.6.3) with the \\\"NETMETA\\\" package. Quality of evidence was evaluated using the CINeMA tool. In total, 26 articles were included for qualitative and 14 articles for quantitative analysis</div></div><div><h3>Results</h3><div>Higher CD1a+ and CD207 + LC levels were observed in low-grade OSCC compared to well and moderately differentiated OSCC. In addition, reductions of CD1a+ and CD207 + LC were associated with locoregional metastasis to lymph nodes. Among OPMDs, oral lichen planus (OLP) showed the highest CD1a+ and CD207 + density. Significant reductions in LC counts were noted in oral leukoplakia (OL), oral submucous fibrosis (OSF), and OSCC. In LSCC, CD1a+ LCs were significantly reduced compared to actinic cheilitis (AC). Sampling and statistical biases were identified in 7 and 17 studies respectively.</div></div><div><h3>Conclusion</h3><div>Differences in CD1a+ and CD207 + LC densities among OSCC, LSCC, and OPMDs may cooperate in understanding of their immunopathogenesis and support diagnostic and therapeutic strategies in these conditions. Furthermore, CD1a+ and CD207 + density reduction may have the potential to be used as a biomarker for oral malignant transformation. In general, a high confidence rate was observed for CD207 + LC and a moderate confidence for CD1a+ LC was noted.</div></div>\",\"PeriodicalId\":8288,\"journal\":{\"name\":\"Archives of oral biology\",\"volume\":\"179 \",\"pages\":\"Article 106372\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of oral biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0003996925002006\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of oral biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003996925002006","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

目的评估朗格汉斯细胞（LC）（CD1a+, CD207 +）在口腔鳞状细胞癌（OSCC），唇鳞状细胞癌（LSCC）和口腔潜在恶性疾病（OPMDs）中是否显示定量差异，因为之前的结果相互矛盾。检索的数据库包括DesignPubMed、Scopus、Embase、Lilacs和Web of Science。该协议已在开放科学框架（OSF）中注册。使用Rayyan软件进行重复删除。采用横截面研究的乔安娜布里格斯研究所（JBI）量表评估偏倚风险。meta分析采用R软件（v3.6.3），附带“NETMETA”软件包。使用CINeMA工具评估证据质量。结果低分级OSCC中CD1a+ 和CD207 + 的LC水平高于分化良好和中分化的OSCC。此外，CD1a+ 和CD207 + LC的减少与局部淋巴结转移有关。口腔扁平苔藓（OLP）中CD1a+ 和CD207 + 密度最高。LC计数在口腔白斑（OL）、口腔黏膜下纤维化（OSF）和OSCC中显著减少。在LSCC中，CD1a+ lc与光化性唇炎（AC）相比显著降低。分别在7项和17项研究中发现了抽样和统计偏差。结论CD1a+ 和CD207 + LC密度在OSCC、LSCC和opmd之间的差异可能有助于了解其免疫发病机制，支持这些疾病的诊断和治疗策略。此外，CD1a+ 和CD207 + 密度降低可能有潜力用作口腔恶性转化的生物标志物。一般来说，CD207 + LC具有较高的置信度，CD1a+ LC具有中等置信度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Different densities of Langerhans cells among oral squamous cell carcinoma, lip squamous cell carcinoma and oral potentially malignant disorders: Systematic review and network meta-analysis

Objective

to evaluate whether Langerhans cells (LC) (CD1a+, CD207 +) show quantification differences in oral squamous cell carcinoma (OSCC), lip squamous cell carcinoma (LSCC), and oral potentially malignant disorders (OPMDs), due to previously conflicting results.

Design

PubMed, Scopus, Embase, Lilacs, and Web of Science were the databases searched. The protocol was registered in the Open Science Framework (OSF). Rayyan software was used for duplicate removal. Risk of bias was assessed using the Joanna Briggs Institute (JBI) scale for cross-sectional studies. Meta-analyses were conducted using R software (v3.6.3) with the "NETMETA" package. Quality of evidence was evaluated using the CINeMA tool. In total, 26 articles were included for qualitative and 14 articles for quantitative analysis

Results

Higher CD1a+ and CD207 + LC levels were observed in low-grade OSCC compared to well and moderately differentiated OSCC. In addition, reductions of CD1a+ and CD207 + LC were associated with locoregional metastasis to lymph nodes. Among OPMDs, oral lichen planus (OLP) showed the highest CD1a+ and CD207 + density. Significant reductions in LC counts were noted in oral leukoplakia (OL), oral submucous fibrosis (OSF), and OSCC. In LSCC, CD1a+ LCs were significantly reduced compared to actinic cheilitis (AC). Sampling and statistical biases were identified in 7 and 17 studies respectively.

Conclusion

Differences in CD1a+ and CD207 + LC densities among OSCC, LSCC, and OPMDs may cooperate in understanding of their immunopathogenesis and support diagnostic and therapeutic strategies in these conditions. Furthermore, CD1a+ and CD207 + density reduction may have the potential to be used as a biomarker for oral malignant transformation. In general, a high confidence rate was observed for CD207 + LC and a moderate confidence for CD1a+ LC was noted.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry