杜氏绿微藻9-顺式β -胡萝卜素的生物合成及生物活性研究

IF 4.5 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Algal Research-Biomass Biofuels and Bioproducts Pub Date : 2025-08-18 DOI:10.1016/j.algal.2025.104270

Shuyang Wu , Xue Wu , Jiahui Wen , Zhengxin Chen , Xinyue Yang , Xinxin He , Congjie Dai , Chao Zhao , Weichao Chen

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引用次数: 0

摘要

随着全球对天然绿色食品和健康相关产品需求的不断增加，迫切需要从藻类中可持续提取营养色素。杜氏藻是一种被广泛研究的模式藻，是天然维生素a的重要来源，特别是富含β-胡萝卜素异构体9-顺式β-胡萝卜素（9CBC）。cbc因其强大的生物活性潜力而被公认为是世界上最昂贵的色素之一。广泛应用于食品、医药、化妆品、动物饲料等行业。此外，9CBC在治疗阿尔茨海默病、视网膜退行性疾病、动脉粥样硬化和其他疾病方面也有治疗应用。然而，9CBC的天然存在是有限的，其合成具有挑战性和昂贵的。本文综述了杜氏藻中9CBC的生物合成途径，并探讨了提高其产量的方法。此外，它简要地讨论了9CBC对各种疾病的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biosynthesis and biological activities of 9-cis beta-carotene from green microalga Dunaliella

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Biosynthesis and biological activities of 9-cis beta-carotene from green microalga Dunaliella

With the increasing global demand for natural green foods and health-related products, there is an urgent need for the sustainable extraction of nutrient pigments from algae. Dunaliella, a widely studied model alga, serves as a significant source of natural vitamin A, particularly rich in the β-carotene isomer, 9-cis β-carotene (9CBC). 9CBC is recognized for its strong bioactive potential and is one of the most expensive pigments worldwide. It is extensively utilized in the food, pharmaceutical, cosmetic, and animal feed industries. Moreover, 9CBC has therapeutic applications in the treatment of Alzheimer's disease, retinal degenerative diseases, atherosclerosis, and other medical conditions. However, the natural occurrence of 9CBC is limited, and its synthesis is challenging and costly. This paper reviews the biosynthetic pathways of 9CBC in Dunaliella and investigates methods to enhance its yield. Furthermore, it briefly discusses the therapeutic potential of 9CBC for various diseases.

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来源期刊

Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

9.40

自引率

7.80%

发文量

332

期刊介绍： Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment