2型糖尿病和体重减轻对MASLD患者血清CK-18的影响

IF 0.4 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Shuang Zhao , Jian-He Gan
{"title":"2型糖尿病和体重减轻对MASLD患者血清CK-18的影响","authors":"Shuang Zhao ,&nbsp;Jian-He Gan","doi":"10.1016/j.nupar.2025.05.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the characteristics of peripheral blood cytokeratin-18 fragments (CK-18) in the development of non-alcoholic fatty liver disease (MASLD), and to find an ideal marker for non-invasive diagnosis of MASLD.</div></div><div><h3>Methods</h3><div>A total of 85 patients with MASLD (abdominal B-ultrasound showed fat deposition) were selected. Serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT) were detected. There were 64 MASLD patients with normal ALT<span> and AST, and 21 MASLD patients with abnormal ALT. Among 64 MASLD patients with normal ALT and AST, 20 patients had type 2 diabetes. Twenty healthy individuals were randomly selected as the control group.</span></div></div><div><h3>Results</h3><div>The level of CK-18 M30 and CK-18 M65 in serum of MASLD patients was higher than that of healthy controls (<em>P</em> <!-->&lt;<!--> <!-->0.05). The serum CK-18 M30 and CK-18 M65 of MASLD patients with abnormal ALT was higher than that of patients with normal ALT and AST (<em>P</em> <!-->&lt;<!--> <!-->0.05). And serum CK18 M30 and CK-18 M65 in MASLD patients were positively correlated with ALT, but not with AST. Among 64 MASLD patients with normal ALT and AST, there was no statistically significant difference in CK-18 M30 and CK-18 M65 between MASLD patients with and without diabetes. Among all MASLD patients, 11 patients lost more than 5 percent of their weight during the study period. Compared with before weight loss, serum CK-18M30 decreased in the 11 patients after weight loss (<em>P</em> <!-->&lt;<!--> <!-->0.05). The decrease of serum CK-18 M65 in the 11 patients was not statistically significant.</div></div><div><h3>Conclusion</h3><div>The level of CK-18 in peripheral blood of MASLD patients is mainly related to serum ALT, but not to diabetes. And weight loss can reduce serum CK-18 M30.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 225-228"},"PeriodicalIF":0.4000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of type 2 diabetes and weight loss on serum CK-18 in MASLD patients\",\"authors\":\"Shuang Zhao ,&nbsp;Jian-He Gan\",\"doi\":\"10.1016/j.nupar.2025.05.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To investigate the characteristics of peripheral blood cytokeratin-18 fragments (CK-18) in the development of non-alcoholic fatty liver disease (MASLD), and to find an ideal marker for non-invasive diagnosis of MASLD.</div></div><div><h3>Methods</h3><div>A total of 85 patients with MASLD (abdominal B-ultrasound showed fat deposition) were selected. Serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT) were detected. There were 64 MASLD patients with normal ALT<span> and AST, and 21 MASLD patients with abnormal ALT. Among 64 MASLD patients with normal ALT and AST, 20 patients had type 2 diabetes. Twenty healthy individuals were randomly selected as the control group.</span></div></div><div><h3>Results</h3><div>The level of CK-18 M30 and CK-18 M65 in serum of MASLD patients was higher than that of healthy controls (<em>P</em> <!-->&lt;<!--> <!-->0.05). The serum CK-18 M30 and CK-18 M65 of MASLD patients with abnormal ALT was higher than that of patients with normal ALT and AST (<em>P</em> <!-->&lt;<!--> <!-->0.05). And serum CK18 M30 and CK-18 M65 in MASLD patients were positively correlated with ALT, but not with AST. Among 64 MASLD patients with normal ALT and AST, there was no statistically significant difference in CK-18 M30 and CK-18 M65 between MASLD patients with and without diabetes. Among all MASLD patients, 11 patients lost more than 5 percent of their weight during the study period. Compared with before weight loss, serum CK-18M30 decreased in the 11 patients after weight loss (<em>P</em> <!-->&lt;<!--> <!-->0.05). The decrease of serum CK-18 M65 in the 11 patients was not statistically significant.</div></div><div><h3>Conclusion</h3><div>The level of CK-18 in peripheral blood of MASLD patients is mainly related to serum ALT, but not to diabetes. And weight loss can reduce serum CK-18 M30.</div></div>\",\"PeriodicalId\":54702,\"journal\":{\"name\":\"Nutrition Clinique et Metabolisme\",\"volume\":\"39 3\",\"pages\":\"Pages 225-228\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Clinique et Metabolisme\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0985056225000470\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0985056225000470","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

目的探讨外周血细胞角蛋白-18片段(CK-18)在非酒精性脂肪性肝病(MASLD)发病过程中的特点,为非酒精性脂肪性肝病(MASLD)的无创诊断寻找理想的标志物。方法选取腹部b超显示脂肪沉积的MASLD患者85例。检测血清谷丙转氨酶(AST)和谷草转氨酶(ALT)。ALT和AST正常的MASLD患者64例,ALT和AST异常的MASLD患者21例,ALT和AST正常的MASLD患者中有20例为2型糖尿病。随机选取20名健康个体作为对照组。结果MASLD患者血清ck - 18m30、ck - 18m65水平明显高于健康对照组(P < 0.05)。ALT异常MASLD患者血清CK-18 M30、CK-18 M65高于ALT、AST正常患者(P < 0.05)。MASLD患者血清CK18 M30和CK-18 M65与ALT呈正相关,与AST无显著正相关。在64例ALT和AST正常的MASLD患者中,CK-18 M30和CK-18 M65在合并和非糖尿病的MASLD患者中差异无统计学意义。在所有MASLD患者中,有11名患者在研究期间体重减轻了5%以上。11例患者减肥后血清CK-18M30均较减肥前下降(P < 0.05)。11例患者血清ck - 18m65降低无统计学意义。结论MASLD患者外周血CK-18水平主要与血清ALT相关,与糖尿病无关。体重减轻可降低血清CK-18 M30。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of type 2 diabetes and weight loss on serum CK-18 in MASLD patients

Objective

To investigate the characteristics of peripheral blood cytokeratin-18 fragments (CK-18) in the development of non-alcoholic fatty liver disease (MASLD), and to find an ideal marker for non-invasive diagnosis of MASLD.

Methods

A total of 85 patients with MASLD (abdominal B-ultrasound showed fat deposition) were selected. Serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT) were detected. There were 64 MASLD patients with normal ALT and AST, and 21 MASLD patients with abnormal ALT. Among 64 MASLD patients with normal ALT and AST, 20 patients had type 2 diabetes. Twenty healthy individuals were randomly selected as the control group.

Results

The level of CK-18 M30 and CK-18 M65 in serum of MASLD patients was higher than that of healthy controls (P < 0.05). The serum CK-18 M30 and CK-18 M65 of MASLD patients with abnormal ALT was higher than that of patients with normal ALT and AST (P < 0.05). And serum CK18 M30 and CK-18 M65 in MASLD patients were positively correlated with ALT, but not with AST. Among 64 MASLD patients with normal ALT and AST, there was no statistically significant difference in CK-18 M30 and CK-18 M65 between MASLD patients with and without diabetes. Among all MASLD patients, 11 patients lost more than 5 percent of their weight during the study period. Compared with before weight loss, serum CK-18M30 decreased in the 11 patients after weight loss (P < 0.05). The decrease of serum CK-18 M65 in the 11 patients was not statistically significant.

Conclusion

The level of CK-18 in peripheral blood of MASLD patients is mainly related to serum ALT, but not to diabetes. And weight loss can reduce serum CK-18 M30.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nutrition Clinique et Metabolisme
Nutrition Clinique et Metabolisme 医学-内分泌学与代谢
CiteScore
0.80
自引率
16.70%
发文量
216
审稿时长
78 days
期刊介绍: Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信