{"title":"MIND饮食与痴呆之间的关系:一项纵向观察荟萃分析","authors":"Hawal Lateef Fateh , Dyari H. Ahmed","doi":"10.1016/j.nupar.2025.04.004","DOIUrl":null,"url":null,"abstract":"<div><div>Dementia, a leading global health concern associated with cognitive decline, has prompted interest in eating patterns to mitigate its onset. This systematic review and meta-analysis examined the impact of the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) on cognitive function and dementia risk. The MIND diet emphasizes neuroprotective foods, such as leafy greens, berries, nuts, whole grains, and fish, with the aim of reducing oxidative stress and inflammation. We reviewed longitudinal studies to evaluate the association between MIND diet adherence and cognitive outcome. A comprehensive literature search across PubMed, Web of Science, Embase, and Cochrane Library identified 14 eligible studies, including longitudinal studies, with a total sample size ranging significantly. Our findings indicate a pooled odds ratio of 0.79 (95% CI: 0.73 to 0.86) for dementia risk, suggesting a significant protective effect of the MIND diet. Additionally, cognitive decline analysis yielded a protective pooled effect size of 0.03 (95% CI: 0.02 to 0.03), albeit with high heterogeneity (I<sup>2</sup> <!-->=<!--> <!-->99.9%). These results underscore the potential of the MIND diet as an effective strategy for promoting cognitive health and reducing dementia risk in older adults. However, the variability in study design and dietary assessment methods suggests the need for further research, including well-designed randomized controlled trials, to establish causal relationships and explore the underlying mechanisms of diet effects.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 199-207"},"PeriodicalIF":0.4000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between MIND diet and dementia: A longitudinal observational meta-analysis\",\"authors\":\"Hawal Lateef Fateh , Dyari H. Ahmed\",\"doi\":\"10.1016/j.nupar.2025.04.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Dementia, a leading global health concern associated with cognitive decline, has prompted interest in eating patterns to mitigate its onset. This systematic review and meta-analysis examined the impact of the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) on cognitive function and dementia risk. The MIND diet emphasizes neuroprotective foods, such as leafy greens, berries, nuts, whole grains, and fish, with the aim of reducing oxidative stress and inflammation. We reviewed longitudinal studies to evaluate the association between MIND diet adherence and cognitive outcome. A comprehensive literature search across PubMed, Web of Science, Embase, and Cochrane Library identified 14 eligible studies, including longitudinal studies, with a total sample size ranging significantly. Our findings indicate a pooled odds ratio of 0.79 (95% CI: 0.73 to 0.86) for dementia risk, suggesting a significant protective effect of the MIND diet. Additionally, cognitive decline analysis yielded a protective pooled effect size of 0.03 (95% CI: 0.02 to 0.03), albeit with high heterogeneity (I<sup>2</sup> <!-->=<!--> <!-->99.9%). These results underscore the potential of the MIND diet as an effective strategy for promoting cognitive health and reducing dementia risk in older adults. However, the variability in study design and dietary assessment methods suggests the need for further research, including well-designed randomized controlled trials, to establish causal relationships and explore the underlying mechanisms of diet effects.</div></div>\",\"PeriodicalId\":54702,\"journal\":{\"name\":\"Nutrition Clinique et Metabolisme\",\"volume\":\"39 3\",\"pages\":\"Pages 199-207\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Clinique et Metabolisme\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0985056225000305\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0985056225000305","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between MIND diet and dementia: A longitudinal observational meta-analysis
Dementia, a leading global health concern associated with cognitive decline, has prompted interest in eating patterns to mitigate its onset. This systematic review and meta-analysis examined the impact of the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) on cognitive function and dementia risk. The MIND diet emphasizes neuroprotective foods, such as leafy greens, berries, nuts, whole grains, and fish, with the aim of reducing oxidative stress and inflammation. We reviewed longitudinal studies to evaluate the association between MIND diet adherence and cognitive outcome. A comprehensive literature search across PubMed, Web of Science, Embase, and Cochrane Library identified 14 eligible studies, including longitudinal studies, with a total sample size ranging significantly. Our findings indicate a pooled odds ratio of 0.79 (95% CI: 0.73 to 0.86) for dementia risk, suggesting a significant protective effect of the MIND diet. Additionally, cognitive decline analysis yielded a protective pooled effect size of 0.03 (95% CI: 0.02 to 0.03), albeit with high heterogeneity (I2 = 99.9%). These results underscore the potential of the MIND diet as an effective strategy for promoting cognitive health and reducing dementia risk in older adults. However, the variability in study design and dietary assessment methods suggests the need for further research, including well-designed randomized controlled trials, to establish causal relationships and explore the underlying mechanisms of diet effects.
期刊介绍:
Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.