过度喂养,Agavins和膳食脂肪:调节斑马鱼肠道微生物群的因素。

IF 1.2
Erick Navarro-Barrón, Crisantema Hernández-González, Raúl Llera-Herrera, Alejandra García-Gasca, Mercedes López-Pérez, Bruno Gómez-Gil
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引用次数: 0

摘要

本研究探讨了低脂饲料过量饲喂对成年雄性斑马鱼(Danio rerio)生物学参数和肠道微生物群的影响。斑马鱼被分配到四个治疗组:两个治疗组接受对照低脂饮食(LF:低脂;LFA:低脂加5%再加蛋白),而其他治疗组喂食过量的低脂饮食(LFO:过量喂食低脂,LFAO:过量喂食低脂加蛋白)。结果表明,低脂过度喂养导致体重增加,超重和肥胖的生物特征指标增加,同时肠道微生物群也发生了显著变化。添加Agavin显著降低了过量喂养组的采食量(p < 0.05),降低了体重和脂肪。多变量分析(置换多变量方差分析和相似性分析)显示,通过16S核糖体RNA基因测序(V3区)评估,LFAO治疗显著影响肠道微生物群组成。在LFA和LFAO之间观察到明显的细菌组成差异,特别是在气单胞菌属,副aburkholderia和Fusobacteriaceae的一个未分类属方面,这导致了这些差异。虽然饮食因素对肠道微生物群的组成影响有限,但饲养方式显示出相当大的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Overfeeding, Agavins, and Dietary Fat: Factors that Modulate the Zebrafish Gut Microbiota.

This study investigates the effects of low-fat diet overfeeding on biological parameters and gut microbiota in adult male zebrafish (Danio rerio). Zebrafish were assigned to four treatment groups: two received control low-fat diets (LF: low-fat; LFA: low-fat with 5% agavins), while the others were overfed these diets (LFO: overfed low-fat; LFAO: overfed low-fat with agavins). Results indicated that low-fat overfeeding led to weight gain and increased biometric indices indicative of overweight and obesity, alongside notable changes in gut microbiota. Agavin supplementation significantly reduced food intake (p < 0.05) and decreased body weight and fat in the overfed groups. Multivariate analyses (permutational multivariate analysis of variance and analysis of similarities) revealed that the LFAO treatment significantly influenced gut microbiota composition, as assessed through 16S ribosomal RNA gene sequencing (V3 region). Noticeable differences in bacterial composition were observed between LFA and LFAO, especially regarding the genera Aeromonas, Paraburkholderia, and an unclassified genus from the Fusobacteriaceae, which contributed to these differences. While dietary factors, specifically agavins, exerted a limited influence on the composition of gut microbiota, the feeding regimen demonstrated a considerable effect.

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