Travis M Fulton, Alfonsina Guelfo, Aziz Elbasheir, Timothy J McDermott, Jiwon Lee, Vishwadeep Ahluwalia, Timothy D Ely, Emma Lathan-Powell, Negar Fani
{"title":"道德伤害的静息状态神经特征:与反刍的关联。","authors":"Travis M Fulton, Alfonsina Guelfo, Aziz Elbasheir, Timothy J McDermott, Jiwon Lee, Vishwadeep Ahluwalia, Timothy D Ely, Emma Lathan-Powell, Negar Fani","doi":"10.1016/j.bpsc.2025.08.001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Moral injury (MI) is a condition that may emerge following a violation of an individual's moral code. MI leads to significant functional impairment in many trauma-exposed civilians with rumination proposed as a mechanism of action. Little is known about the neuropathophysiology of different MI dimensions, including MI related to transgressions caused by the self or others. We examined links between facets of MI, resting-state amplitude of low frequency fluctuations (ALFF) and rumination in trauma-exposed civilians.</p><p><strong>Methods: </strong>Sixty adults (18-65 years, 51 female) completed measures of moral injury (Moral Injury Exposure and Symptom Scale for Civilians, MIESS-C), rumination (Response Styles Questionnaire, RSQ), and resting-state fMRI. Voxel-wise linear regression on ALFF was performed with rumination and MIESS-C-derived self, other, and betrayal-related MI as regressors.</p><p><strong>Results: </strong>Betrayal-related MI associated with higher ALFF in the bilateral precuneus and left medial prefrontal cortex. Other-related MI associated with lower ALFF in the left dorsolateral prefrontal cortex and insula (voxel-wise p<.001, cluster false discovery rate-corrected p<.05). Rumination severity was positively associated with betrayal-related ALFF clusters in the bilateral precuneus r =0.32, p =0.012, and left medial prefrontal cortex, r =0.31, p =0.017.</p><p><strong>Conclusions: </strong>Results reveal distinct neural signatures of MI, with betrayal-related MI associated with greater ALFF in default mode network regions, and this activation related to rumination severity. Other-related MI linked with diminished activation in cognitive control and interoceptive network regions, which may reflect physiological withdrawal. These signatures are attractive candidate neuromodulatory targets.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415846/pdf/","citationCount":"0","resultStr":"{\"title\":\"Resting-state Neural Signatures of Moral Injury: Associations with Rumination.\",\"authors\":\"Travis M Fulton, Alfonsina Guelfo, Aziz Elbasheir, Timothy J McDermott, Jiwon Lee, Vishwadeep Ahluwalia, Timothy D Ely, Emma Lathan-Powell, Negar Fani\",\"doi\":\"10.1016/j.bpsc.2025.08.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Moral injury (MI) is a condition that may emerge following a violation of an individual's moral code. MI leads to significant functional impairment in many trauma-exposed civilians with rumination proposed as a mechanism of action. Little is known about the neuropathophysiology of different MI dimensions, including MI related to transgressions caused by the self or others. We examined links between facets of MI, resting-state amplitude of low frequency fluctuations (ALFF) and rumination in trauma-exposed civilians.</p><p><strong>Methods: </strong>Sixty adults (18-65 years, 51 female) completed measures of moral injury (Moral Injury Exposure and Symptom Scale for Civilians, MIESS-C), rumination (Response Styles Questionnaire, RSQ), and resting-state fMRI. Voxel-wise linear regression on ALFF was performed with rumination and MIESS-C-derived self, other, and betrayal-related MI as regressors.</p><p><strong>Results: </strong>Betrayal-related MI associated with higher ALFF in the bilateral precuneus and left medial prefrontal cortex. Other-related MI associated with lower ALFF in the left dorsolateral prefrontal cortex and insula (voxel-wise p<.001, cluster false discovery rate-corrected p<.05). Rumination severity was positively associated with betrayal-related ALFF clusters in the bilateral precuneus r =0.32, p =0.012, and left medial prefrontal cortex, r =0.31, p =0.017.</p><p><strong>Conclusions: </strong>Results reveal distinct neural signatures of MI, with betrayal-related MI associated with greater ALFF in default mode network regions, and this activation related to rumination severity. Other-related MI linked with diminished activation in cognitive control and interoceptive network regions, which may reflect physiological withdrawal. These signatures are attractive candidate neuromodulatory targets.</p>\",\"PeriodicalId\":93900,\"journal\":{\"name\":\"Biological psychiatry. 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Resting-state Neural Signatures of Moral Injury: Associations with Rumination.
Background: Moral injury (MI) is a condition that may emerge following a violation of an individual's moral code. MI leads to significant functional impairment in many trauma-exposed civilians with rumination proposed as a mechanism of action. Little is known about the neuropathophysiology of different MI dimensions, including MI related to transgressions caused by the self or others. We examined links between facets of MI, resting-state amplitude of low frequency fluctuations (ALFF) and rumination in trauma-exposed civilians.
Methods: Sixty adults (18-65 years, 51 female) completed measures of moral injury (Moral Injury Exposure and Symptom Scale for Civilians, MIESS-C), rumination (Response Styles Questionnaire, RSQ), and resting-state fMRI. Voxel-wise linear regression on ALFF was performed with rumination and MIESS-C-derived self, other, and betrayal-related MI as regressors.
Results: Betrayal-related MI associated with higher ALFF in the bilateral precuneus and left medial prefrontal cortex. Other-related MI associated with lower ALFF in the left dorsolateral prefrontal cortex and insula (voxel-wise p<.001, cluster false discovery rate-corrected p<.05). Rumination severity was positively associated with betrayal-related ALFF clusters in the bilateral precuneus r =0.32, p =0.012, and left medial prefrontal cortex, r =0.31, p =0.017.
Conclusions: Results reveal distinct neural signatures of MI, with betrayal-related MI associated with greater ALFF in default mode network regions, and this activation related to rumination severity. Other-related MI linked with diminished activation in cognitive control and interoceptive network regions, which may reflect physiological withdrawal. These signatures are attractive candidate neuromodulatory targets.