道德伤害的静息状态神经特征:与反刍的关联。

IF 4.8
Travis M Fulton, Alfonsina Guelfo, Aziz Elbasheir, Timothy J McDermott, Jiwon Lee, Vishwadeep Ahluwalia, Timothy D Ely, Emma Lathan-Powell, Negar Fani
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引用次数: 0

摘要

背景:道德伤害(MI)是在违反个人道德准则后可能出现的一种情况。在许多创伤暴露的平民中,心肌梗死导致显著的功能损伤,反刍被认为是一种作用机制。目前对不同程度的心肌梗死的神经病理生理学知之甚少,包括与自我或他人引起的犯罪相关的心肌梗死。我们研究了创伤暴露平民脑梗死各方面、静息状态低频波动幅度(ALFF)和反刍之间的联系。方法:60名成年人(18-65岁,女性51名)完成道德伤害量表(平民道德伤害暴露与症状量表,miss - c)、反刍(反应风格问卷,RSQ)和静息态功能磁共振成像(fMRI)。以反刍和miss - c衍生的自我、他人和背叛相关的MI作为回归量,对ALFF进行体素线性回归。结果:背叛相关性心肌梗死与双侧楔前叶和左侧内侧前额叶皮层ALFF增高有关。其他相关的心肌梗死与左背外侧前额叶皮层和脑岛较低的ALFF相关(体素方向)。结论:研究结果揭示了心肌梗死的不同神经特征,背叛相关的心肌梗死与默认模式网络区域较高的ALFF相关,这种激活与反刍严重程度相关。其他相关的心肌梗死与认知控制和内感受网络区域的激活减少有关,这可能反映了生理戒断。这些特征是有吸引力的候选神经调节靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resting-state Neural Signatures of Moral Injury: Associations with Rumination.

Background: Moral injury (MI) is a condition that may emerge following a violation of an individual's moral code. MI leads to significant functional impairment in many trauma-exposed civilians with rumination proposed as a mechanism of action. Little is known about the neuropathophysiology of different MI dimensions, including MI related to transgressions caused by the self or others. We examined links between facets of MI, resting-state amplitude of low frequency fluctuations (ALFF) and rumination in trauma-exposed civilians.

Methods: Sixty adults (18-65 years, 51 female) completed measures of moral injury (Moral Injury Exposure and Symptom Scale for Civilians, MIESS-C), rumination (Response Styles Questionnaire, RSQ), and resting-state fMRI. Voxel-wise linear regression on ALFF was performed with rumination and MIESS-C-derived self, other, and betrayal-related MI as regressors.

Results: Betrayal-related MI associated with higher ALFF in the bilateral precuneus and left medial prefrontal cortex. Other-related MI associated with lower ALFF in the left dorsolateral prefrontal cortex and insula (voxel-wise p<.001, cluster false discovery rate-corrected p<.05). Rumination severity was positively associated with betrayal-related ALFF clusters in the bilateral precuneus r =0.32, p =0.012, and left medial prefrontal cortex, r =0.31, p =0.017.

Conclusions: Results reveal distinct neural signatures of MI, with betrayal-related MI associated with greater ALFF in default mode network regions, and this activation related to rumination severity. Other-related MI linked with diminished activation in cognitive control and interoceptive network regions, which may reflect physiological withdrawal. These signatures are attractive candidate neuromodulatory targets.

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