{"title":"阿尔茨海默病病理机制的文献计量学分析：基于小鼠模型的应用。","authors":"Jinjiang Li, Zhaoxiong Lin, Yufei Niu, Wenrui Chang, Siyun Song, Guang Yang, Feng Liu, Jiaxin Dai, Chunyan Hao","doi":"10.1177/25424823251367046","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. Animal models play a key role in exploring its pathophysiological mechanisms.</p><p><strong>Objective: </strong>To analyze global research trends and knowledge structure in AD pathophysiological mechanisms based on animal models.</p><p><strong>Methods: </strong>Publications from 2014 to 2023 were retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer were used for bibliometric analysis and data visualization.</p><p><strong>Results: </strong>A total of 2169 publications were identified, with a steady growth trend. The United States and China were the leading contributors, with Harvard University as a major collaborative hub. The Journal of Alzheimer's Disease published the most articles, while the Journal of Neuroscience had the highest co-citation frequency. Holtzman DM was a key author in the field. Nine keyword clusters were identified, including insulin resistance, amyloid beta, and oxidative stress. Emerging topics include synapse loss, gut microbiota, and NLRP3 inflammasome.</p><p><strong>Conclusions: </strong>This study provides a concise overview of global research on AD pathophysiological mechanisms in animal models, offering valuable insights for future research directions.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251367046"},"PeriodicalIF":2.8000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351105/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bibliometric analysis of pathological mechanisms in Alzheimer's disease: Applications based on mouse models.\",\"authors\":\"Jinjiang Li, Zhaoxiong Lin, Yufei Niu, Wenrui Chang, Siyun Song, Guang Yang, Feng Liu, Jiaxin Dai, Chunyan Hao\",\"doi\":\"10.1177/25424823251367046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. Animal models play a key role in exploring its pathophysiological mechanisms.</p><p><strong>Objective: </strong>To analyze global research trends and knowledge structure in AD pathophysiological mechanisms based on animal models.</p><p><strong>Methods: </strong>Publications from 2014 to 2023 were retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer were used for bibliometric analysis and data visualization.</p><p><strong>Results: </strong>A total of 2169 publications were identified, with a steady growth trend. The United States and China were the leading contributors, with Harvard University as a major collaborative hub. The Journal of Alzheimer's Disease published the most articles, while the Journal of Neuroscience had the highest co-citation frequency. Holtzman DM was a key author in the field. Nine keyword clusters were identified, including insulin resistance, amyloid beta, and oxidative stress. Emerging topics include synapse loss, gut microbiota, and NLRP3 inflammasome.</p><p><strong>Conclusions: </strong>This study provides a concise overview of global research on AD pathophysiological mechanisms in animal models, offering valuable insights for future research directions.</p>\",\"PeriodicalId\":73594,\"journal\":{\"name\":\"Journal of Alzheimer's disease reports\",\"volume\":\"9 \",\"pages\":\"25424823251367046\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351105/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/25424823251367046\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25424823251367046","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：阿尔茨海默病（AD）是一种以记忆丧失和认知能力下降为特征的进行性神经退行性疾病。动物模型在探索其病理生理机制方面发挥着关键作用。目的：分析基于动物模型的阿尔茨海默病病理生理机制的国际研究趋势和知识结构。方法：检索Web of Science Core Collection中2014 - 2023年的出版物。使用CiteSpace和VOSviewer进行文献计量分析和数据可视化。结果：共收录文献2169篇，并呈稳定增长趋势。美国和中国是主要的贡献者，哈佛大学是一个主要的合作中心。《阿尔茨海默病杂志》发表的文章最多，而《神经科学杂志》的共同引用频率最高。Holtzman DM是该领域的重要作者。确定了9个关键词簇，包括胰岛素抵抗、β淀粉样蛋白和氧化应激。新出现的主题包括突触丢失、肠道微生物群和NLRP3炎性体。结论：本研究对全球AD动物模型病理生理机制的研究进行了简要综述，为今后的研究方向提供了有价值的见解。
Bibliometric analysis of pathological mechanisms in Alzheimer's disease: Applications based on mouse models.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. Animal models play a key role in exploring its pathophysiological mechanisms.
Objective: To analyze global research trends and knowledge structure in AD pathophysiological mechanisms based on animal models.
Methods: Publications from 2014 to 2023 were retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer were used for bibliometric analysis and data visualization.
Results: A total of 2169 publications were identified, with a steady growth trend. The United States and China were the leading contributors, with Harvard University as a major collaborative hub. The Journal of Alzheimer's Disease published the most articles, while the Journal of Neuroscience had the highest co-citation frequency. Holtzman DM was a key author in the field. Nine keyword clusters were identified, including insulin resistance, amyloid beta, and oxidative stress. Emerging topics include synapse loss, gut microbiota, and NLRP3 inflammasome.
Conclusions: This study provides a concise overview of global research on AD pathophysiological mechanisms in animal models, offering valuable insights for future research directions.
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