{"title":"m6A调节剂ELF3在口腔鳞状细胞癌中的下调及其对癌变和预后的影响","authors":"Karpakavinayakam Gopalakrishnan, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam","doi":"10.1016/j.jormas.2025.102532","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Oral squamous cell carcinoma (OSCC) is a prevalent and invasive cancer with poor prognosis, demanding the identification of innovative biomarkers and therapeutic targets. Currently, there is a growing concern on the role of novel m6A reader E74-like factor 3 (ELF3) in tumorigenesis. This study investigated the oncogenic role of ELF3 in OSCC.</p><p><strong>Methods: </strong>Expression of ELF3 in OSCC tissues was analyzed using a comprehensive approach, including RT-qPCR, western blotting, and IHC. The Cancer Genome Atlas (TCGA-HNSCC) dataset and clinicopathological features along with immune signatures in patients with HNSCC were analyzed. The survival rate of patients with HNSCC was studied with Kaplan-Meier analysis. Moreover, bioinformatic strategies were used to analyze ELF3 protein networks and functional pathways involved in oral carcinogenesis.</p><p><strong>Results: </strong>ELF3 is downregulated in OSCC tumor tissues and is associated with advanced clinicopathologic features, nodal metastasis and poorer survival outcome. From the functional enrichment analysis, ELF3 participates in core pathways such as DNA transcription, transcriptional dysregulation in cancer, NOTCH translation and oral carcinoma pathways. Additionally, a negative correlation exists between ELF3 expression levels and immune cell infiltration, as well as immune gene modulation in the tumor microenvironment.</p><p><strong>Conclusion: </strong>Our findings imply that ELF3 can be used as a promising biomarker for OSCC prognosis along with a therapeutic target to reduce cancer metastasis and enhance patient outcomes. Additional research is required to corroborate these findings and investigate the molecular pathways associated with ELF3 function in OSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102532"},"PeriodicalIF":2.0000,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Downregulation of the m6A modulator ELF3 and its impact on carcinogenesis and prognosis in oral squamous cell carcinoma.\",\"authors\":\"Karpakavinayakam Gopalakrishnan, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam\",\"doi\":\"10.1016/j.jormas.2025.102532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Oral squamous cell carcinoma (OSCC) is a prevalent and invasive cancer with poor prognosis, demanding the identification of innovative biomarkers and therapeutic targets. Currently, there is a growing concern on the role of novel m6A reader E74-like factor 3 (ELF3) in tumorigenesis. This study investigated the oncogenic role of ELF3 in OSCC.</p><p><strong>Methods: </strong>Expression of ELF3 in OSCC tissues was analyzed using a comprehensive approach, including RT-qPCR, western blotting, and IHC. The Cancer Genome Atlas (TCGA-HNSCC) dataset and clinicopathological features along with immune signatures in patients with HNSCC were analyzed. The survival rate of patients with HNSCC was studied with Kaplan-Meier analysis. Moreover, bioinformatic strategies were used to analyze ELF3 protein networks and functional pathways involved in oral carcinogenesis.</p><p><strong>Results: </strong>ELF3 is downregulated in OSCC tumor tissues and is associated with advanced clinicopathologic features, nodal metastasis and poorer survival outcome. From the functional enrichment analysis, ELF3 participates in core pathways such as DNA transcription, transcriptional dysregulation in cancer, NOTCH translation and oral carcinoma pathways. Additionally, a negative correlation exists between ELF3 expression levels and immune cell infiltration, as well as immune gene modulation in the tumor microenvironment.</p><p><strong>Conclusion: </strong>Our findings imply that ELF3 can be used as a promising biomarker for OSCC prognosis along with a therapeutic target to reduce cancer metastasis and enhance patient outcomes. Additional research is required to corroborate these findings and investigate the molecular pathways associated with ELF3 function in OSCC.</p>\",\"PeriodicalId\":56038,\"journal\":{\"name\":\"Journal of Stomatology Oral and Maxillofacial Surgery\",\"volume\":\" \",\"pages\":\"102532\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Stomatology Oral and Maxillofacial Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jormas.2025.102532\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stomatology Oral and Maxillofacial Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jormas.2025.102532","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
Downregulation of the m6A modulator ELF3 and its impact on carcinogenesis and prognosis in oral squamous cell carcinoma.
Objective: Oral squamous cell carcinoma (OSCC) is a prevalent and invasive cancer with poor prognosis, demanding the identification of innovative biomarkers and therapeutic targets. Currently, there is a growing concern on the role of novel m6A reader E74-like factor 3 (ELF3) in tumorigenesis. This study investigated the oncogenic role of ELF3 in OSCC.
Methods: Expression of ELF3 in OSCC tissues was analyzed using a comprehensive approach, including RT-qPCR, western blotting, and IHC. The Cancer Genome Atlas (TCGA-HNSCC) dataset and clinicopathological features along with immune signatures in patients with HNSCC were analyzed. The survival rate of patients with HNSCC was studied with Kaplan-Meier analysis. Moreover, bioinformatic strategies were used to analyze ELF3 protein networks and functional pathways involved in oral carcinogenesis.
Results: ELF3 is downregulated in OSCC tumor tissues and is associated with advanced clinicopathologic features, nodal metastasis and poorer survival outcome. From the functional enrichment analysis, ELF3 participates in core pathways such as DNA transcription, transcriptional dysregulation in cancer, NOTCH translation and oral carcinoma pathways. Additionally, a negative correlation exists between ELF3 expression levels and immune cell infiltration, as well as immune gene modulation in the tumor microenvironment.
Conclusion: Our findings imply that ELF3 can be used as a promising biomarker for OSCC prognosis along with a therapeutic target to reduce cancer metastasis and enhance patient outcomes. Additional research is required to corroborate these findings and investigate the molecular pathways associated with ELF3 function in OSCC.
期刊介绍：
J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics.
Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.
All manuscripts submitted to the journal are subjected to peer review by international experts, and must:
Be written in excellent English, clear and easy to understand, precise and concise;
Bring new, interesting, valid information - and improve clinical care or guide future research;
Be solely the work of the author(s) stated;
Not have been previously published elsewhere and not be under consideration by another journal;
Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed.
Under no circumstances does the journal guarantee publication before the editorial board makes its final decision.
The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.
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