儿童肝移植受者新发特应性疾病的患病率及危险因素：一项回顾性队列研究

IF 4.3 2区医学 Q2 ALLERGY

World Allergy Organization Journal Pub Date : 2025-08-10 eCollection Date: 2025-08-01 DOI:10.1016/j.waojou.2025.101102

Krittapaun Sombatwatthana, Watcharoot Kanchongkittiphon, Potjanee Kiewngam, Wanlapa Jotikasthira, Songpon Getsuwan, Napapat Butsriphum, Wiparat Manuyakorn, Suporn Treepongkaruna

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引用次数: 0

摘要

背景：特应性疾病在儿童肝移植（LT）受者中很常见，但其患病率、缓解程度和危险因素尚不清楚。目的：调查儿童肝移植受者食物过敏（FA）、变应性鼻炎（AR）和哮喘的患病率、发病、缓解和危险因素。结果：118名儿童肝移植受者中，71名（60.2%）在移植后发生特应性疾病。新发FA最常见（40.7%），中位发病时间为lt后9.5个月。大多数病例是ige介导的，牛奶和鸡蛋是最常见的过敏原。超过3年，56.3%的人至少摆脱了一种过敏食物。诊断为AR的占24.4%，屋尘螨是主要致敏变应原。哮喘发病率较低（3.4%）。结论：新生FA和AR在儿童肝移植受者中很常见，与移植年龄、EBV再激活和遗传易感显著相关。早期监测和干预对于控制这一人群的特应性疾病至关重要。

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Prevalence and risk factors of de novo atopic diseases in pediatric liver transplant recipients: A retrospective cohort study.

Background: Atopic diseases are common in pediatric liver transplant (LT) recipients, yet their prevalence, remission, and risk factors remain unclear.

Objective: To investigate the prevalence, onset, remission, and risk factors for food allergy (FA), allergic rhinitis (AR), and asthma in pediatric LT recipients.

Results: Among 118 pediatric LT recipients, 71 (60.2%) developed atopic diseases post-transplant. De novo FA was the most common (40.7%), with a median onset of 9.5 months after LT. Most cases were IgE-mediated, with cow's milk and egg as the most common allergens. Over 3 years, 56.3% outgrew at least one allergic food. AR was diagnosed in 24.4%, with house dust mites as the primary sensitizing allergens. Asthma was less frequent (3.4%). Younger age at LT (<2 years) significantly increased FA risk (OR: 5.5, 95% CI: 2.0-15.2), as did Epstein-Barr virus (EBV) reactivation (OR: 6.5, 95% CI: 1.2-33.8). AR risk was higher in those with a first-degree family history of atopy (OR: 5.6, 95% CI: 2.1-14.7) or an atopic organ donor (OR: 4.6, 95% CI: 1.3-16.2).

Conclusion: De novo FA and AR are common in pediatric LT recipients, with significant associations with age at transplant, EBV reactivation, and genetic predisposition. Early monitoring and intervention are crucial to managing atopic diseases in this population.

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来源期刊

World Allergy Organization Journal Immunology and Microbiology-Immunology

CiteScore

9.10

自引率

5.90%

发文量

审稿时长

9 weeks

期刊介绍： The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.