外周血单核细胞作为种子细胞在外周神经修复中的探索性研究进展。

IF 3.7 4区 医学 Q2 NEUROSCIENCES
Neural Plasticity Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI:10.1155/np/8895041
Yi Chen, Yubin Wen, Mingyue Zhang, Jing Nie, Guangfeng Sun
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引用次数: 0

摘要

外周神经损伤(PNI)是一种常见的临床疾病,通常由机械性创伤或肿瘤切除引起,经常引起持续的感觉缺陷、运动障碍、神经性疼痛或瘫痪。因此,受影响的个人承受了沉重的社会经济负担。自体神经移植常被认为是周围神经缺损重建的首选方法;然而,该技术存在局限性,包括供体部位感觉丧失、移植物长度受限和神经不匹配。近年来,外周血单核细胞(peripheral blood mononuclear cells, PBMCs)因其可及性、免疫调节特性和神经修复潜力而成为神经再生研究的热点。然而,pbmc介导的神经修复的确切机制尚未完全确定,其分子通路需要进一步阐明。本研究探讨了pbmc在促进周围神经再生中的潜在作用,特别关注了它们通过调节Hook1表达和相关分子途径对逆行脑源性神经营养因子(BDNF)转运的调节。本研究旨在为基于pbmc的治疗策略提供新的见解,并为临床翻译奠定理论基础。对pbmc在神经再生中的实施挑战和转化前景也进行了批判性评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair.

Peripheral nerve injury (PNI) represents a prevalent clinical condition, often resulting from mechanical trauma or tumor resection, which frequently induces persistent sensory deficits, motor impairment, neuropathic pain, or paralysis. Consequently, substantial socioeconomic burdens are imposed on affected individuals. Autologous nerve transplantation is often considered the preferred approach for reconstructing peripheral nerve defects; however, this technique is associated with limitations including donor-site sensory loss, restricted graft length, and nerve mismatches. Recently, peripheral blood mononuclear cells (PBMCs) have emerged as a focal point in nerve regeneration research due to their accessibility, immunomodulatory properties, and neuro-reparative potential. Nevertheless, the precise mechanisms underlying PBMC-mediated nerve repair remain incompletely characterized, and their molecular pathways require further elucidation. This study explores the potential role of PBMCs in promoting peripheral nerve regeneration, with a particular focus on their regulation of retrograde brain-derived neurotrophic factor (BDNF) transport through modulation of Hook1 expression and associated molecular pathways. This research seeks to provide novel insights for PBMC-based therapeutic strategies and establish a theoretical foundation for clinical translation. Implementation challenges and translational prospects for PBMCs in nerve regeneration are also critically evaluated.

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来源期刊
Neural Plasticity
Neural Plasticity NEUROSCIENCES-
CiteScore
6.80
自引率
0.00%
发文量
77
审稿时长
16 weeks
期刊介绍: Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.
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