Haiying Zhang, Yang Zhao, Yi Chen, Yuanyuan Feng, Bo Shen, Shuangshuang Dong, Jun Zhu, Xu Jiang, Dongfeng Li, Yaning Chen, Feng Han, Li Zhang
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Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson's disease.
Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson's disease (PD) and precede the onset of well-structured visual hallucinations (VH). Whether the number of MH is associated with VH in PD patients remains unclear. We investigated the association between the number of MH and VH in 372 PD patients. Log-binomial regressions showed that individuals with multiple MH had a significantly higher prevalence of VH (RR = 2.08, 95% CI: 1.11-3.90 for 2 MH; RR = 6.20, 95% CI: 3.40-11.31 for 3 MH), while those with only one MH had a similar VH prevalence compared to those without MH (RR = 1.08, 95% CI: 0.53-2.21). Women exhibited stronger associations than men. These findings emphasize the importance of quantifying MH subtypes when assessing hallucinations, though their potential utility as predictive markers of disease progression and targets for early intervention requires validation through longitudinal studies.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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