有丝分裂疗法恢复线粒体功能并改善阿尔茨海默病的认知缺陷。

IF 4.5 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2025-08-15 DOI:10.1016/j.mito.2025.102077

Tulika Gupta , Asha Rao , Veena Devi , Lalita Kumari , Akshita Negi , Munish Kumar , Ranjana Bharti , Bikash Medhi

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引用次数: 0

摘要

线粒体功能障碍是阿尔茨海默病（AD）的一个标志，导致认知能力下降。本研究探讨了线粒体移植在减轻AD患者认知能力下降方面的治疗潜力。将具有结构和功能特征的年轻大鼠脑线粒体静脉移植到AD大鼠中。共聚焦成像证实外源标记线粒体整合到海马组织中。有丝分裂治疗后，我们通过神经行为测试发现认知能力显著改善，淀粉样蛋白前体蛋白水平显著降低。进一步改善线粒体功能参数；减少氧化应激，改善线粒体膜电位和钙稳态。这些发现强调了有丝分裂疗法是治疗阿尔茨海默病的一种很有前途的策略。

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Mitotherapy Restores mitochondrial function and improves cognitive deficits in Alzheimer’s disease

Mitochondrial dysfunction is a hallmark of Alzheimer’s disease (AD), contributing to cognitive decline. This study explores the therapeutic potential of mitochondrial transplantation in mitigating cognitive decline in AD. Structurally and functionally characterized mitochondria from young rat brains were intravenously transplanted into AD rats. Confocal imaging confirmed integration of exogenous tagged mitochondria into hippocampal tissue. Post-mitotherapy, we noted significant cognitive improvement by neurobehavioral tests and significant reduction in protein levels of amyloid precursor protein. Further mitochondrial functional parameters improved; reduced oxidative stress, improved mitochondrial membrane potential, and calcium homeostasis. These findings highlight mitotherapy as a promising strategy for treating Alzheimer’s disease.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.