抗核糖体- p蛋白抗体与系统性红斑狼疮(SLE):在丹麦成年SLE患者的横断面研究中,未发现抗核糖体- p与神经精神性SLE之间存在显著关联。

IF 3.5 2区 医学 Q1 RHEUMATOLOGY
Sabine Lerke Kamstrup, Nanna Surlemont Schmidt, Henrik Zachar Langkilde, Anna Christine Nilsson, Anne Voss
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引用次数: 0

摘要

目的:主要目的是评估抗核糖体- p蛋白抗体(抗rib - p)在典型的丹麦成年SLE队列中的患病率。次要目标包括(1)评估抗rib - p与神经精神性SLE (NPSLE)之间的关联,(2)评估抗rib - p与丹麦SLE患者特征之间的关联,(3)评估选定的自身抗体与NPSLE之间的潜在关联。方法:这项横断面研究纳入了198名丹麦SLE患者,他们来自一个以人群为基础的队列。患者符合美国风湿病学会1997年修订的SLE分类标准,年龄≥18岁。采用荧光酶免疫法检测血清中抗rib - p的含量。用间接免疫荧光法检测HEp-2细胞的ANA模式。手工ELISA检测抗双链DNA抗体,Luminex仪器检测Ro/SSA、La/SSB、Sm、RNP、Scl-70、Jo-1、中心体B和组蛋白抗体。结果:我们确定了14例(7.1%)抗rib - p阳性SLE患者,3例抗rib - p阳性患者被诊断为NPSLE(占NPSLE患者的21%)。anti-Rib-P与NPSLE之间无统计学意义。NPSLE患者的平均抗rib - p滴度与非NPSLE患者的平均抗rib - p滴度无显著差异。我们观察到通过SLEDAI-2K (SLE疾病活动指数2000)评分测量的抗rib - p阳性与疾病活动之间存在显著关联。逐步逻辑回归发现NPSLE与SLEDAI-2K和SLICC DI (SLE国际合作诊所损害指数)评分之间存在关联。结论:本研究不能证实抗rib - p在NPSLE鉴定中的作用。另一方面,抗rib - p与SLE疾病活动性和器官损伤有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Anti-ribosomal-P protein antibodies and systemic lupus erythematosus (SLE): in a cross-sectional study of Danish adult patients with SLE, no significant association is found between anti-ribosomal-P and neuropsychiatric SLE.

Anti-ribosomal-P protein antibodies and systemic lupus erythematosus (SLE): in a cross-sectional study of Danish adult patients with SLE, no significant association is found between anti-ribosomal-P and neuropsychiatric SLE.

Objective: The primary objective was to assess the prevalence of anti-ribosomal-P protein antibodies (anti-Rib-P) in a well-characterised Danish adult SLE cohort. Secondary objectives included (1) assessing any association between anti-Rib-P and neuropsychiatric SLE (NPSLE), (2) assessing any association between anti-Rib-P and characteristics of Danish patients with SLE and (3) assessing potential associations between selected autoantibodies and NPSLE.

Method: This cross-sectional study included 198 Danish patients with SLE from a population-based cohort. Patients meet the American College of Rheumatology's 1997 revised classification criteria for SLE and were 18 years of age or older. Anti-Rib-P were detected in serum using fluorescence enzyme immunoassay. ANA patterns were tested using indirect immunofluorescence on HEp-2 cells. Anti-double-stranded DNA antibody was examined by manual ELISA, and antibodies targeting Ro/SSA, La/SSB, Sm, RNP, Scl-70, Jo-1, Centromer B and Histone were examined on a Luminex instrument.

Results: We identified 14 (7.1%) patients with anti-Rib-P positive SLE, and 3 anti-Rib-P positive patients were diagnosed with NPSLE (21% of patients with NPSLE). There was no statistically significant association between anti-Rib-P and NPSLE. The mean anti-Rib-P titres in the patients with NPSLE did not differ significantly from patients without NPSLE patients' titres. We observed a significant association between anti-Rib-P positivity and disease activity measured by the SLEDAI-2K (SLE Disease Activity Index 2000) score. A stepwise logistic regression found an association between NPSLE and SLEDAI-2K and SLICC DI (SLE International Collaborating Clinics Damage Index) score.

Conclusion: This study could not confirm a role for anti-Rib-P in the identification of NPSLE. On the other hand, anti-Rib-P was associated with SLE disease activity as well as organ damage.

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来源期刊
Lupus Science & Medicine
Lupus Science & Medicine RHEUMATOLOGY-
CiteScore
5.30
自引率
7.70%
发文量
88
审稿时长
15 weeks
期刊介绍: Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.
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