Mohammad Mehdi Abbasi, Mahdyeh Karimi, Sajjad Khandae, Bahram Rashidkhani
{"title":"食物不安全是阿尔茨海默病的重要危险因素:一项病例对照研究。","authors":"Mohammad Mehdi Abbasi, Mahdyeh Karimi, Sajjad Khandae, Bahram Rashidkhani","doi":"10.34172/jrhs.7824","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is a gap in the literature specifically addressing the relationship between food insecurity and the risk of Alzheimer's disease (AD). <b>Study Design:</b> A case-control study.</p><p><strong>Methods: </strong>This study aimed to evaluate the association between food insecurity and the risk of AD in 301 participants, including 150 cases and 151 controls. Cases were recruited among people in the early stages of the disease who had been diagnosed with AD within the past six months. Controls were selected from health centers across Tehran. Food security status was assessed using the validated Persian translation of the 18-item United States Department of Agriculture's household food security questionnaire.</p><p><strong>Results: </strong>After adjusting for potential cofounders, food insecurity was associated with a higher risk of AD (odds ratio [OR]: 2.80; 95% confidence interval [CI]: 1.59-4.94). Among female participants, food insecurity increased the odds of AD (OR: 3.54; 95% CI: 1.72-7.30). For individuals under 65, food insecurity also increased the likelihood of AD nearly four-fold (OR: 3.94, 95% CI: 1.48-10.47), while for those over 65, the risk was only 2.89 times (OR: 2.89, 95% CI: 1.36-6.14).</p><p><strong>Conclusion: </strong>Food insecurity might be associated with an increased risk of AD. Further research is required to explore the relationship between food insecurity and other types of neurological disorders or health conditions. More precisely, future studies should aim to investigate the association in a prospective design.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"25 3","pages":"e00652"},"PeriodicalIF":1.4000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445880/pdf/","citationCount":"0","resultStr":"{\"title\":\"Food Insecurity Is an Important Risk Factor for Alzheimer's Disease: A Case-Control Study.\",\"authors\":\"Mohammad Mehdi Abbasi, Mahdyeh Karimi, Sajjad Khandae, Bahram Rashidkhani\",\"doi\":\"10.34172/jrhs.7824\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is a gap in the literature specifically addressing the relationship between food insecurity and the risk of Alzheimer's disease (AD). <b>Study Design:</b> A case-control study.</p><p><strong>Methods: </strong>This study aimed to evaluate the association between food insecurity and the risk of AD in 301 participants, including 150 cases and 151 controls. Cases were recruited among people in the early stages of the disease who had been diagnosed with AD within the past six months. Controls were selected from health centers across Tehran. Food security status was assessed using the validated Persian translation of the 18-item United States Department of Agriculture's household food security questionnaire.</p><p><strong>Results: </strong>After adjusting for potential cofounders, food insecurity was associated with a higher risk of AD (odds ratio [OR]: 2.80; 95% confidence interval [CI]: 1.59-4.94). Among female participants, food insecurity increased the odds of AD (OR: 3.54; 95% CI: 1.72-7.30). For individuals under 65, food insecurity also increased the likelihood of AD nearly four-fold (OR: 3.94, 95% CI: 1.48-10.47), while for those over 65, the risk was only 2.89 times (OR: 2.89, 95% CI: 1.36-6.14).</p><p><strong>Conclusion: </strong>Food insecurity might be associated with an increased risk of AD. Further research is required to explore the relationship between food insecurity and other types of neurological disorders or health conditions. More precisely, future studies should aim to investigate the association in a prospective design.</p>\",\"PeriodicalId\":17164,\"journal\":{\"name\":\"Journal of research in health sciences\",\"volume\":\"25 3\",\"pages\":\"e00652\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445880/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of research in health sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/jrhs.7824\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of research in health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/jrhs.7824","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Food Insecurity Is an Important Risk Factor for Alzheimer's Disease: A Case-Control Study.
Background: There is a gap in the literature specifically addressing the relationship between food insecurity and the risk of Alzheimer's disease (AD). Study Design: A case-control study.
Methods: This study aimed to evaluate the association between food insecurity and the risk of AD in 301 participants, including 150 cases and 151 controls. Cases were recruited among people in the early stages of the disease who had been diagnosed with AD within the past six months. Controls were selected from health centers across Tehran. Food security status was assessed using the validated Persian translation of the 18-item United States Department of Agriculture's household food security questionnaire.
Results: After adjusting for potential cofounders, food insecurity was associated with a higher risk of AD (odds ratio [OR]: 2.80; 95% confidence interval [CI]: 1.59-4.94). Among female participants, food insecurity increased the odds of AD (OR: 3.54; 95% CI: 1.72-7.30). For individuals under 65, food insecurity also increased the likelihood of AD nearly four-fold (OR: 3.94, 95% CI: 1.48-10.47), while for those over 65, the risk was only 2.89 times (OR: 2.89, 95% CI: 1.36-6.14).
Conclusion: Food insecurity might be associated with an increased risk of AD. Further research is required to explore the relationship between food insecurity and other types of neurological disorders or health conditions. More precisely, future studies should aim to investigate the association in a prospective design.
期刊介绍:
The Journal of Research in Health Sciences (JRHS) is the official journal of the School of Public Health; Hamadan University of Medical Sciences, which is published quarterly. Since 2017, JRHS is published electronically. JRHS is a peer-reviewed, scientific publication which is produced quarterly and is a multidisciplinary journal in the field of public health, publishing contributions from Epidemiology, Biostatistics, Public Health, Occupational Health, Environmental Health, Health Education, and Preventive and Social Medicine. We do not publish clinical trials, nursing studies, animal studies, qualitative studies, nutritional studies, health insurance, and hospital management. In addition, we do not publish the results of laboratory and chemical studies in the field of ergonomics, occupational health, and environmental health