抗生素会引发神经炎症。

IF 10.6 1区医学 Q1 IMMUNOLOGY

Journal of Experimental Medicine Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI:10.1084/jem.20251233

Jessica E Kenison, Francisco J Quintana

引用次数: 0

摘要

肠道微生物组通过微生物代谢物TMAVA介导的机制调节小胶质细胞激活，从而限制急性移植物抗宿主病的神经炎症和神经认知能力下降（Chatterjee et al. https://doi.org/10.1084/jem.20242180）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibiotics unleash neuroinflammation.

The gut microbiome limits neuroinflammation and neurocognitive decline in acute graft-versus-host disease by modulating microglial activation via a mechanism mediated by the microbial metabolite TMAVA (Chatterjee et al. https://doi.org/10.1084/jem.20242180).

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来源期刊

Journal of Experimental Medicine 医学-免疫学

CiteScore

26.60

自引率

1.30%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field. Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions. Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.