不再有FOMO: NOMO和calm将机械生物学扩展到急诊室。

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-09-01 Epub Date: 2025-08-18 DOI:10.1083/jcb.202508037

Julie Heffler, Jan Lammerding

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引用次数: 0

摘要

细胞机械转导的研究主要集中在细胞表面和细胞骨架上。在本期中，Naughton等人（https://doi.org/10.1083/jcb.202505010）发现内质网（ER）常驻蛋白NOMO是一种在肌肉分化和功能中起关键作用的受力元件。在一项补充研究中，Merta等人（https://doi.org/10.1016/j.celrep.2025.115502）证明，镇静在局灶黏附处将内质网小管束缚在肌动蛋白丝上，调节其功能。

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FOMO no more: NOMO and calmin extend mechanobiology to the ER.

Research on cellular mechanotransduction has primarily focused on the cell surface and the cytoskeleton. In this issue, Naughton et al. (https://doi.org/10.1083/jcb.202505010) identify NOMO, an endoplasmic reticulum (ER)-resident protein, as a force-bearing element with crucial roles in muscle differentiation and function. In a complementary study, Merta et al. (https://doi.org/10.1016/j.celrep.2025.115502) demonstrate that calmin physically tethers ER tubules to actin filaments at focal adhesions, modulating their function.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.