优化线圈设计增强电场感应周围神经刺激。

IF 5.2 2区 医学 Q2 ENGINEERING, BIOMEDICAL
Jaeu Park;Kyeong Jae Lee;Pritish Nagwade;Jinwoong Jeong;Jeong Hoan Park;Hongsoo Choi;Sohee Kim;Sanghoon Lee
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引用次数: 0

摘要

周围神经电刺激被广泛应用于神经性疼痛的治疗和神经再生。然而,它经常引起不良的生物反应和周围神经组织的意外激活。作为替代方案,周围神经磁刺激提供了一种有前途的、侵入性较小的方法,可以在不直接接触组织的情况下实现靶向神经刺激。尽管它有潜力,但它受到线圈体积大和由于所需的高电流而产生过多热量的限制。为了解决这些局限性,我们进行了一项优化周围神经调节线圈设计的研究。我们的方法在模拟和动物实验的支持下,专注于优化线圈几何形状以最大化感应电场梯度。在各种设计中,四叶菱形线圈在界面中心显示出最高的梯度。在大鼠坐骨神经实验中,该线圈在上升时间为200 μs、振幅为25 V的矩形脉冲驱动下,成功地激发了胫骨前肌和腓肠肌的复合肌肉动作电位。本研究提出了基于磁刺激替代传统电刺激的周围神经刺激(PNS)线圈的设计指南。所提出的方法可能为开发先进、小型化和节能的神经刺激线圈奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimized Coil Design for Enhanced Electric Field Induction in Peripheral Nerve Stimulation
Peripheral nerve electrical stimulation is widely used for the treatment of neuropathic pain and neural regeneration. However, it often induces adverse biological reactions and unintended activation of surrounding neural tissues. As an alternative, peripheral nerve magnetic stimulation offers a promising, less invasive approach that enables targeted nerve stimulation without direct tissue contact. Despite its potential, it is constrained by the bulkiness of coils and excessive heat generation due to the high currents required. To address these limitations, we conducted a study on coil design optimized for peripheral nerve modulation. Our approach, supported by simulations and animal experiments, focused on optimizing coil geometry to maximize the induced electric field gradient. Among various designs, a four-leaf rhombus-shaped coil demonstrated the highest gradient at the center of the interface. In rat sciatic nerve experiments, this coil, driven by a rectangular pulse with a $200~\mu $ s rise time and 25 V amplitude, successfully elicited compound muscle action potentials in both the tibial anterior and gastrocnemius muscles. This study presents design guidelines for peripheral nerve stimulation (PNS) coils based on magnetic stimulation as an alternative to conventional electrical stimulation. The proposed approach may serve as a foundation for the development of advanced, miniaturized, and energy-efficient neural stimulation coils.
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来源期刊
CiteScore
8.60
自引率
8.20%
发文量
479
审稿时长
6-12 weeks
期刊介绍: Rehabilitative and neural aspects of biomedical engineering, including functional electrical stimulation, acoustic dynamics, human performance measurement and analysis, nerve stimulation, electromyography, motor control and stimulation; and hardware and software applications for rehabilitation engineering and assistive devices.
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