血液病患儿有机氯农药残留研究

IF 1.5 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-08-19 DOI:10.1007/s13312-025-00159-6

Rachit Khandelwal, Sumaira Khalil, Vipin Tyagi, Mrinalini Kotru, Basu Dev Banerjee, Sunil Gomber, Pooja Dewan

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The median (Q1, Q3) serum total OCPs (ng/mL) were significantly higher in children with malignant and non-malignant HDs compared to controls [38.67 (33.64, 42.51); 32.72 (17.26, 41.60); and 14.11 (12.82, 16.40)]; levels were significantly higher in the malignant versus non-malignant HD group. The median (Q1, Q3) serum levels of total hexachlorocyclohexane [3.30 (2.23, 4.28) vs. 2.16 (1.31, 3.31) ng/mL] and β-hexachlorocyclohexane [0.98 (0.67, 1.68) vs. 0.54 (0.10, 0.77) ng/mL] levels were significantly higher in children with non-malignant HDs compared to malignant HD, respectively. 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引用次数: 0

摘要

目的：比较恶性和非恶性血液病（hd）患儿血清和骨髓中有机氯农药（OCP）残留量与健康对照。方法：本病例对照研究在≤12岁的恶性和非恶性hd患儿和非贫血健康对照中进行。患有先天性畸形、神经发育障碍和慢性全身性疾病的儿童被排除在外。采用气液色谱/63Ni电子捕获检测法测定血清和骨髓抽吸液中的OCPs。结果：共纳入30例儿童，分别为恶性hd、非恶性hd和对照组。恶性和非恶性hd患儿血清总OCPs （ng/mL）中位数（Q1, Q3）均显著高于对照组[38.67 (33.64,42.51)；32.72 (17.26, 41.60)；14.11 (12.82, 16.40)]；恶性HD组的水平明显高于非恶性HD组。非恶性HD患儿血清总六氯环己烷[3.30（2.23,4.28）比2.16 (1.31,3.31)ng/mL]和β-六氯环己烷[0.98（0.67,1.68）比0.54 (0.10,0.77)ng/mL]水平的中位值（Q1, Q3）分别显著高于恶性HD患儿。恶性HD组中位（Q1, Q3）总骨髓OCPs (ng/mL)[23.53(20.83, 26.91)]明显高于非恶性HD组[17.41 (0,25.63)]；非恶性HD组骨髓硫丹II （ng/mL）含量[1.56(0.56,3.89)]明显高于恶性HD组[0.45(0.35,1.72)]。结论：adhd患儿血清中OCP残留量明显高于对照组。恶性hd患儿血清和骨髓中累积的OCP残留量明显高于非恶性hd患儿。

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Organochlorine Pesticide Residues in Children with Hematological Disorders.

Objectives: To compare the levels of organochlorine pesticide (OCP) residues in sera and bone marrow of children with malignant and non-malignant hematological disorders (HDs) with those in healthy controls.

Methods: This case-control study was conducted among children aged ≤ 12 years with malignant and non-malignant HDs and non-anemic healthy controls. Children with gross congenital malformations, neurodevelopmental disorders, and chronic systemic diseases were excluded. OCPs were estimated in sera and bone marrow aspirate using gas-liquid chromatography/⁶³Ni electron capture detection.

Results: Thirty children, each, with malignant HDs, non-malignant HDs, and controls, were included. The median (Q1, Q3) serum total OCPs (ng/mL) were significantly higher in children with malignant and non-malignant HDs compared to controls [38.67 (33.64, 42.51); 32.72 (17.26, 41.60); and 14.11 (12.82, 16.40)]; levels were significantly higher in the malignant versus non-malignant HD group. The median (Q1, Q3) serum levels of total hexachlorocyclohexane [3.30 (2.23, 4.28) vs. 2.16 (1.31, 3.31) ng/mL] and β-hexachlorocyclohexane [0.98 (0.67, 1.68) vs. 0.54 (0.10, 0.77) ng/mL] levels were significantly higher in children with non-malignant HDs compared to malignant HD, respectively. The median (Q1, Q3) total bone marrow OCPs (ng/mL) were significantly higher in the malignant HD group [23.53 (20.83, 26.91)] compared to the non-malignant HD group [17.41 (0, 25.63)]; bone marrow endosulfan II (ng/mL) was significantly higher in the non-malignant HD group [1.56 (0.56, 3.89)] compared to malignant HD group [0.45 (0.35, 1.72)].

Conclusion: Children with HDs had significantly higher OCP residues in sera compared to controls. The cumulative OCP residues in sera and bone marrow were significantly higher in children with malignant versus non-malignant HDs.

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.