慢性精神分裂症患者的甲状腺激素和认知功能:一项大规模横断面研究。

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY
Shutong Yang, Ke Zhang, Rui Jiang, Yuanyuan Liu, Cui Li, Guoshuai Luo, Xiangyang Zhang
{"title":"慢性精神分裂症患者的甲状腺激素和认知功能:一项大规模横断面研究。","authors":"Shutong Yang, Ke Zhang, Rui Jiang, Yuanyuan Liu, Cui Li, Guoshuai Luo, Xiangyang Zhang","doi":"10.1007/s00406-025-02085-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cognitive dysfunction is a core symptom in chronic schizophrenia, yet the mechanisms underlying these impairments remain poorly understood. Thyroid hormones have been suggested to influence cognitive function in various psychiatric disorders, but their role in schizophrenia remains unclear. This study aimed to explore the relationship between thyroid hormone levels and cognitive performance in patients with chronic schizophrenia.</p><p><strong>Methods: </strong>A total of 1271 patients with chronic schizophrenia were included in this cross-sectional study. Cognitive function was assessed using the repeatable battery for the assessment of neuropsychological status (RBANS), while thyroid hormone levels (total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4)) were measured. Data analysis included linear correlation and regression models to examine the relationships between thyroid hormones and cognitive performance.</p><p><strong>Results: </strong>Significant associations were found between thyroid hormone levels and cognitive function. FT3 was positively correlated with visuospatial (r = 0.055, p < 0.05), while TT4 showed a negative correlation with immediate memory, visuospatial, language, and attention (r = -0.109 to -0.068, p < 0.05). Regression analysis further confirmed that TT4 was a negative predictor for immediate memory, visuospatial, language, and attention, while FT3 emerged as a positive predictor for visuospatial.</p><p><strong>Conclusions: </strong>This study provides evidence for the role of thyroid hormones in cognitive dysfunction in chronic schizophrenia, with TT4 negatively related to multiple cognitive domains, and FT3 positively associated with visuospatial ability. These findings suggest that thyroid hormone imbalances may contribute to cognitive impairments in schizophrenia and warrant further investigation into potential therapeutic interventions.</p>","PeriodicalId":11822,"journal":{"name":"European Archives of Psychiatry and Clinical Neuroscience","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thyroid hormones and cognitive function in chronic schizophrenia: a large-scale cross-sectional study.\",\"authors\":\"Shutong Yang, Ke Zhang, Rui Jiang, Yuanyuan Liu, Cui Li, Guoshuai Luo, Xiangyang Zhang\",\"doi\":\"10.1007/s00406-025-02085-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cognitive dysfunction is a core symptom in chronic schizophrenia, yet the mechanisms underlying these impairments remain poorly understood. Thyroid hormones have been suggested to influence cognitive function in various psychiatric disorders, but their role in schizophrenia remains unclear. This study aimed to explore the relationship between thyroid hormone levels and cognitive performance in patients with chronic schizophrenia.</p><p><strong>Methods: </strong>A total of 1271 patients with chronic schizophrenia were included in this cross-sectional study. Cognitive function was assessed using the repeatable battery for the assessment of neuropsychological status (RBANS), while thyroid hormone levels (total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4)) were measured. Data analysis included linear correlation and regression models to examine the relationships between thyroid hormones and cognitive performance.</p><p><strong>Results: </strong>Significant associations were found between thyroid hormone levels and cognitive function. FT3 was positively correlated with visuospatial (r = 0.055, p < 0.05), while TT4 showed a negative correlation with immediate memory, visuospatial, language, and attention (r = -0.109 to -0.068, p < 0.05). Regression analysis further confirmed that TT4 was a negative predictor for immediate memory, visuospatial, language, and attention, while FT3 emerged as a positive predictor for visuospatial.</p><p><strong>Conclusions: </strong>This study provides evidence for the role of thyroid hormones in cognitive dysfunction in chronic schizophrenia, with TT4 negatively related to multiple cognitive domains, and FT3 positively associated with visuospatial ability. These findings suggest that thyroid hormone imbalances may contribute to cognitive impairments in schizophrenia and warrant further investigation into potential therapeutic interventions.</p>\",\"PeriodicalId\":11822,\"journal\":{\"name\":\"European Archives of Psychiatry and Clinical Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Archives of Psychiatry and Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00406-025-02085-x\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Archives of Psychiatry and Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00406-025-02085-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:认知功能障碍是慢性精神分裂症的核心症状,但其机制尚不清楚。甲状腺激素已被认为影响各种精神疾病的认知功能,但其在精神分裂症中的作用尚不清楚。本研究旨在探讨慢性精神分裂症患者甲状腺激素水平与认知能力的关系。方法:对1271例慢性精神分裂症患者进行横断面研究。使用可重复电池评估神经心理状态(rban)评估认知功能,同时测量甲状腺激素水平(总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4))。数据分析包括线性相关和回归模型,以检验甲状腺激素与认知表现之间的关系。结果:甲状腺激素水平与认知功能之间存在显著相关性。结论:本研究为甲状腺激素在慢性精神分裂症认知功能障碍中的作用提供了证据,其中TT4与多个认知领域负相关,FT3与视觉空间能力正相关。这些发现表明,甲状腺激素失衡可能导致精神分裂症患者的认知障碍,值得进一步研究潜在的治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thyroid hormones and cognitive function in chronic schizophrenia: a large-scale cross-sectional study.

Background: Cognitive dysfunction is a core symptom in chronic schizophrenia, yet the mechanisms underlying these impairments remain poorly understood. Thyroid hormones have been suggested to influence cognitive function in various psychiatric disorders, but their role in schizophrenia remains unclear. This study aimed to explore the relationship between thyroid hormone levels and cognitive performance in patients with chronic schizophrenia.

Methods: A total of 1271 patients with chronic schizophrenia were included in this cross-sectional study. Cognitive function was assessed using the repeatable battery for the assessment of neuropsychological status (RBANS), while thyroid hormone levels (total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4)) were measured. Data analysis included linear correlation and regression models to examine the relationships between thyroid hormones and cognitive performance.

Results: Significant associations were found between thyroid hormone levels and cognitive function. FT3 was positively correlated with visuospatial (r = 0.055, p < 0.05), while TT4 showed a negative correlation with immediate memory, visuospatial, language, and attention (r = -0.109 to -0.068, p < 0.05). Regression analysis further confirmed that TT4 was a negative predictor for immediate memory, visuospatial, language, and attention, while FT3 emerged as a positive predictor for visuospatial.

Conclusions: This study provides evidence for the role of thyroid hormones in cognitive dysfunction in chronic schizophrenia, with TT4 negatively related to multiple cognitive domains, and FT3 positively associated with visuospatial ability. These findings suggest that thyroid hormone imbalances may contribute to cognitive impairments in schizophrenia and warrant further investigation into potential therapeutic interventions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信