Current clinical and surgical insights in the workup and management of Wilms tumor (nephroblastoma).

Purpose of review: Wilms tumor remains the most common renal malignancy in children. The treatment of Wilms tumor has evolved over the past decades improving overall survival while decreasing long-term, treatment-related sequelae. The purpose of this review is to provide a nuanced overview of Wilms tumor diagnosis, staging, and treatment with a particular emphasis on current advances in the field.

Recent findings: Differences and similarities exist between international treatment protocols set forth by the Children's Oncology Group (COG) and the International Society of Pediatric Urology (SIOP). Risk stratification is evolving with the use of molecular and histopathologic markers as outlined by the UMBRELLA protocol. The emphasis on survivorship care and long-term effects of treatment on patients with Wilms tumor remains a shared aim across groups.

Summary: Understanding the presentation, workup, management, and posttreatment effects of Wilms tumor is clinically relevant to all providers, as patients require multidisciplinary care beyond the initial oncologic setting.