{"title":"慢性全闭塞患者c反应蛋白、尿酸白蛋白比与冠状动脉侧枝循环的关系","authors":"Kadir Karacali, Tugba Kapansahin, Damla Yalcinkaya Oner, Bilal Canberk Ilhan, Anil Salman, Mikail Yarlioglu","doi":"10.1097/MCA.0000000000001564","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>C-reactive protein and uric acid to albumin ratio (CUAR) is a recent inflammatory marker associated with cardiovascular disease. We aim to investigate the relationship between CUAR and coronary collateral circulation (CCC) in patients with stable coronary artery disease and chronic total occlusion (CTO).</p><p><strong>Methods: </strong>The patients were divided into two groups; 267 patients with poor CCC formation group and 133 patients with well CCC formation group. CUARlog was calculated using the 'log10 (CRP × UA/Albumin)' formula.</p><p><strong>Results: </strong>CUARlog levels were significantly higher in patients with poor CCC formation (P < 0.001). CUARlog levels above 1.45 predicted poor CCC with a higher sensitivity of 70% and specificity of 67% than uric acid to albumin ratio (UAR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) (P < 0.001). In the comparison of the AUC values, there was a significant difference between the CUARlog and UAR (P = 0.047), NLR (P = 0.001), and PLR (P < 0.001). In multivariate regression analysis, CUARlog above 1.45 (P < 0.001) was associated independently with poor CCC occurrence.</p><p><strong>Conclusion: </strong>Our results suggested that CUARlog is a more potent and independent marker than other inflammatory markers to predict poor CCC occurrence in CTO patients. It may be useful to identify high-risk patients with poor CCC occurrence.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between C-reactive protein and uric acid to albumin ratio and coronary collateral circulation in patients with chronic total occlusion.\",\"authors\":\"Kadir Karacali, Tugba Kapansahin, Damla Yalcinkaya Oner, Bilal Canberk Ilhan, Anil Salman, Mikail Yarlioglu\",\"doi\":\"10.1097/MCA.0000000000001564\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>C-reactive protein and uric acid to albumin ratio (CUAR) is a recent inflammatory marker associated with cardiovascular disease. We aim to investigate the relationship between CUAR and coronary collateral circulation (CCC) in patients with stable coronary artery disease and chronic total occlusion (CTO).</p><p><strong>Methods: </strong>The patients were divided into two groups; 267 patients with poor CCC formation group and 133 patients with well CCC formation group. CUARlog was calculated using the 'log10 (CRP × UA/Albumin)' formula.</p><p><strong>Results: </strong>CUARlog levels were significantly higher in patients with poor CCC formation (P < 0.001). CUARlog levels above 1.45 predicted poor CCC with a higher sensitivity of 70% and specificity of 67% than uric acid to albumin ratio (UAR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) (P < 0.001). In the comparison of the AUC values, there was a significant difference between the CUARlog and UAR (P = 0.047), NLR (P = 0.001), and PLR (P < 0.001). In multivariate regression analysis, CUARlog above 1.45 (P < 0.001) was associated independently with poor CCC occurrence.</p><p><strong>Conclusion: </strong>Our results suggested that CUARlog is a more potent and independent marker than other inflammatory markers to predict poor CCC occurrence in CTO patients. It may be useful to identify high-risk patients with poor CCC occurrence.</p>\",\"PeriodicalId\":10702,\"journal\":{\"name\":\"Coronary artery disease\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coronary artery disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MCA.0000000000001564\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronary artery disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCA.0000000000001564","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Relationship between C-reactive protein and uric acid to albumin ratio and coronary collateral circulation in patients with chronic total occlusion.
Objective: C-reactive protein and uric acid to albumin ratio (CUAR) is a recent inflammatory marker associated with cardiovascular disease. We aim to investigate the relationship between CUAR and coronary collateral circulation (CCC) in patients with stable coronary artery disease and chronic total occlusion (CTO).
Methods: The patients were divided into two groups; 267 patients with poor CCC formation group and 133 patients with well CCC formation group. CUARlog was calculated using the 'log10 (CRP × UA/Albumin)' formula.
Results: CUARlog levels were significantly higher in patients with poor CCC formation (P < 0.001). CUARlog levels above 1.45 predicted poor CCC with a higher sensitivity of 70% and specificity of 67% than uric acid to albumin ratio (UAR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) (P < 0.001). In the comparison of the AUC values, there was a significant difference between the CUARlog and UAR (P = 0.047), NLR (P = 0.001), and PLR (P < 0.001). In multivariate regression analysis, CUARlog above 1.45 (P < 0.001) was associated independently with poor CCC occurrence.
Conclusion: Our results suggested that CUARlog is a more potent and independent marker than other inflammatory markers to predict poor CCC occurrence in CTO patients. It may be useful to identify high-risk patients with poor CCC occurrence.
期刊介绍：
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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