非儿童患者同种异体造血干细胞移植(alloo - hsct)后造血重建期间的ARDS:基于新的全球定义。

IF 3.4 3区 医学 Q1 RESPIRATORY SYSTEM
Chang Gao, Ying Wang, Di Yin, Daxiong Zeng, Ye Gao, Yu He, Yuanyuan Yang, Haiyan Wang, Depei Wu, Qiang Guo
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引用次数: 0

摘要

背景:造血重建以免疫抑制和全血细胞减少为特征,代表了同种异体造血干细胞移植(alloo - hsct)后最初的高危期。然而,关于在造血重建过程中急性呼吸窘迫综合征(ARDS)的发生知之甚少。方法:本回顾性队列研究纳入2016年至2019年在苏州接受同种异体造血干细胞移植的1024例患者。临床数据和随访信息从医疗记录中收集。ARDS是根据2023年制定的新的全球定义定义的。主要结果是同种异体造血干细胞移植后造血重建期间ARDS的发生率和移植后1年的死亡率。结果:1024例患者中,58例(5.6%)在移植后1年内死亡。45例(4.4%)患者在造血重建过程中发生ARDS,其中29例仅采用高流量鼻吸氧治疗。ARDS的中位发病时间为移植后9.0天。发生ARDS的患者在移植后1年死亡的风险明显更高(HR 7.99, 95% CI 4.13 ~ 15.44)。造血重建期间ARDS的独立危险因素包括发病和移植间隔时间较长(OR 1.01, 95% CI 1.00 - 1.02),既往hsct数量较多(OR 1.82, 95% CI 1.04 - 3.19),入院时红细胞分布宽度较高(OR 1.12, 95% CI 1.02 - 1.22)。结论:根据新的2023年全球定义,造血重建期间的ARDS与同种异体造血干细胞移植后1年死亡率的增加独立相关。在此期间早期发现ARDS尤为重要,认识其危险因素可能有助于及时诊断和干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ARDS during haematopoietic reconstruction after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in non-child patients: based on the new global definition.

ARDS during haematopoietic reconstruction after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in non-child patients: based on the new global definition.

ARDS during haematopoietic reconstruction after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in non-child patients: based on the new global definition.

ARDS during haematopoietic reconstruction after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in non-child patients: based on the new global definition.

Background: Haematopoietic reconstitution is marked by immunosuppression and pancytopenia, representing the initial high-risk period following allogeneic haematopoietic stem cell transplantation (allo-HSCT). However, little is known about the occurrence of acute respiratory distress syndrome (ARDS) during haematopoietic reconstitution.

Methods: This retrospective cohort study included 1024 patients who underwent allo-HSCT in Suzhou from 2016 to 2019. Clinical data and follow-up information were collected from medical records. ARDS was defined according to the new global definition established in 2023. The primary outcomes were the incidence of ARDS during haematopoietic reconstitution after allo-HSCT and 1 year post-transplantation mortality.

Results: Among the 1024 patients, 58 (5.6%) died within 1 year after HSCT. ARDS during haematopoietic reconstitution occurred in 45 patients (4.4%), of whom 29 were treated with high-flow nasal oxygen only. The median onset of ARDS was 9.0 days post-transplantation. Patients who developed ARDS had a significantly higher risk of 1-year mortality after HSCT (HR 7.99, 95% CI 4.13 to 15.44). Independent risk factors for ARDS during haematopoietic reconstitution included longer intervals between disease onset and transplantation (OR 1.01, 95% CI 1.00 to 1.02), a greater number of previous HSCTs (OR 1.82, 95% CI 1.04 to 3.19), and higher red cell distribution width at admission (OR 1.12, 95% CI 1.02 to 1.22).

Conclusions: According to the new 2023 global definition, ARDS during haematopoietic reconstitution is independently associated with increased 1-year mortality after allo-HSCT. Early identification of ARDS during this period is particularly important, and recognising its risk factors may aid in timely diagnosis and intervention.

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来源期刊
BMJ Open Respiratory Research
BMJ Open Respiratory Research RESPIRATORY SYSTEM-
CiteScore
6.60
自引率
2.40%
发文量
95
审稿时长
12 weeks
期刊介绍: BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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