Sono-And Mechanochemistry-Assisted Dual Strategies for Cyanomethylation of Carboxylic Acids: Robust and Practical Synthetic Protocols to a Diverse Series of Cyanomethyl Esters.

We herein disclose a dual synthetic approach involving sonochemical and mechanochemical strategies for a diverse series of cyanomethyl esters of carboxylic acids. Both synthetic protocols offer a straightforward, efficient, and practical alternative to preparing this important class of biologically and synthetically promising organic compounds. Significant advantages of the newly developed methods include mild reaction conditions, avoidance of any metal catalysts and external oxidants, shorter reaction times (in minutes), good to excellent yields, broad substrate scope and tolerance of other various functional groups, gram-scale applicability, and reusability of the solid surface.