Li Hong Hong, Jian Zhi Zhang, Zi Han Gao, Jie Yang, Hai Yao Yang, Jun Ming Liu and Zhi-Yuan Li*,
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Seeing, Counting, Identifying, and Distinguishing Single Molecules from Their Mixtures via Raman Spectroscopy
Seeing, counting, identifying, and distinguishing molecules one by one in their mixture phases is recognized as a big challenge in molecular science. Here we employ this using a single-molecule surface-enhanced Raman spectroscopy (SM-SERS) strategy combining giant electromagnetic enhancement (EME) from plasmonic nanogaps and giant chemical enhancement (CME) from monolayer WS2. For a dilute mixture of rhodamine B (RhB), rhodamine 6G (R6G), and crystal violet (CV) at concentrations of as low as 10–16 M, this SM-SERS substrate enables the sighting, counting, identification, and distinction of individual molecules. High-credibility results are achieved rapidly (50 ms acquisition) using 785 nm near-infrared laser excitation to record and analyze distinct Raman spectra. This EME-CME synergy SM-SERS strategy offers a powerful capability of optically probing and monitoring the spatial–temporal evolution of the physical, chemical, and biological properties of molecules, which would open up a new frontier of molecular science.
期刊介绍：
Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including:
- Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale
- Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies
- Modeling and simulation of synthetic, assembly, and interaction processes
- Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance
- Applications of nanoscale materials in living and environmental systems
Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.
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