梯度溶剂替代介导的高强度水凝胶形成微针的长期给药研究（Sci. 30/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-08-20 DOI:10.1002/advs.71156

Hui Li, Fengzhen Meng, Chengwei Hu, Zhiyun Wu, Liuzhi Hao, Caijun Sun, Lijing Fang, Fan Pan, Shaoquan Bian, Huipeng Li, Mingjun Li, Bo Liu, Xiaoli Zhao

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引用次数: 0

摘要

封面图片描绘了一艘破冰的船，象征着通过梯度溶剂替代设计的微针系统，克服了传统水凝胶微针需要脱水才能获得足够强度的局限性。该系统在完全水合状态下实现角质层渗透，并根据组织液引发的pH值变化实现持续的药物释放。更多细节可以在文章编号2500833中找到，作者是刘博、赵晓丽和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gradient Solvent Replacement-Mediated Formation of High-Strength Hydrogel-Forming Microneedle for Long-Term Drug Delivery (Adv. Sci. 30/2025)

查看原文本刊更多论文

Gradient Solvent Replacement-Mediated Formation of High-Strength Hydrogel-Forming Microneedle for Long-Term Drug Delivery (Adv. Sci. 30/2025)

High-Strength Microneedle Patches

The cover image features a ship breaking through ice, symbolizing the microneedle system engineered via gradient solvent replacement that overcomes the limitations of traditional hydrogel microneedles, which require dehydration to gain sufficient strength. This system achieves stratum corneum penetration in a fully hydrated state and enables sustained drug release in response to pH changes triggered by tissue fluids. More details can be found in article number 2500833 by Bo Liu, Xiaoli Zhao, and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.