Julien van Delft, Chikahiro Imashiro, Yuta Kurashina, Makoto Hirano, Jun Homma, Shinsuke Mochizuki, Hideharu Shimozawa, Kenjiro Takemura
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In article number 2500092, Kenjiro Takemura and co-workers demonstrate that ultrasound-based, enzyme-free cell detachment accelerates spheroid formation by preserving surface proteins, reducing variability, and enhancing cell aggregation. Comparable engraftment and improved spatial organization in co-cultured spheroids were observed. These findings suggest ultrasound detachment as a robust alternative for efficient, high-quality spheroid production in tissue engineering and related biomedical applications.