Viviane Valdes, Dashiell D. Sacks, Jennifer Near, Adriana S. Méndez Leal, Andrea G. Edlow, Carmen D. Zorrilla, Charles A. Nelson
{"title":"产前暴露于SARS-CoV-2和寨卡病毒后婴儿全脑频谱功率差异：来自马萨诸塞州波士顿和波多黎各圣胡安的队列研究结果","authors":"Viviane Valdes, Dashiell D. Sacks, Jennifer Near, Adriana S. Méndez Leal, Andrea G. Edlow, Carmen D. Zorrilla, Charles A. Nelson","doi":"10.1002/jdn.70047","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Viral exposure during pregnancy is associated with adverse outcomes in offspring. Given the increasing frequency of viral outbreaks both locally and globally, the current study sought to examine the impact of antenatal exposure to Zika virus (ZIKV) and SARS-CoV-2 on infant neurophysiological development during the first year of life.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Families were recruited from two cohorts, one in San Juan, Puerto Rico (ZIKV) and one in Boston, Massachusetts (SARS-CoV-2). For the ZIKV cohort, infants were assessed cross-sectionally between 3 to 12 months of age. For SARS-CoV-2, infants were assessed longitudinally at 3, 6, 9 and 12 months. Electroencephalography (EEG) was used to compare absolute power during a resting state task across the whole brain (by spectral band) between infants with antenatal viral exposure and nonexposed infants. Data were analysed using generalized linear models (GLMs) and multilevel mixed effects models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In the ZIKV cohort, age-by-exposure interactions were observed for delta (<i>p</i> = 0.027) and theta power (<i>p</i> = 0.009), where exposed infants demonstrated decreasing power with age, while nonexposed infants demonstrated increasing power with age from 3 to 12 months. In the SARS-CoV-2 cohort, antenatally exposed children had lower levels of beta (<i>p</i> = 0.022) and gamma power (<i>p</i> = 0.044) overall from 3 to 12 months. Significant recovery was observed in trajectories for beta power by 12 months.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>ZIKV exposure during pregnancy was associated with reductions in low-frequency EEG power, which may be indicative of disruptions in early brain maturation. SARS-CoV-2 exposure was associated with reductions in higher-frequency power, suggesting potential impairments on sensorimotor and cognitive integration. Increases in beta power by 12 months in the SARS-CoV-2 cohort indicate some recovery, although potential compounding and sleeper effects from early disruptions are possible.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 5","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Whole Brain Spectral Power Differences During Infancy Following Antenatal SARS-CoV-2 and Zika Virus Exposure: Findings From Cohorts in Boston, Massachusetts and San Juan, Puerto Rico\",\"authors\":\"Viviane Valdes, Dashiell D. Sacks, Jennifer Near, Adriana S. Méndez Leal, Andrea G. Edlow, Carmen D. Zorrilla, Charles A. Nelson\",\"doi\":\"10.1002/jdn.70047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Viral exposure during pregnancy is associated with adverse outcomes in offspring. Given the increasing frequency of viral outbreaks both locally and globally, the current study sought to examine the impact of antenatal exposure to Zika virus (ZIKV) and SARS-CoV-2 on infant neurophysiological development during the first year of life.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Families were recruited from two cohorts, one in San Juan, Puerto Rico (ZIKV) and one in Boston, Massachusetts (SARS-CoV-2). For the ZIKV cohort, infants were assessed cross-sectionally between 3 to 12 months of age. For SARS-CoV-2, infants were assessed longitudinally at 3, 6, 9 and 12 months. Electroencephalography (EEG) was used to compare absolute power during a resting state task across the whole brain (by spectral band) between infants with antenatal viral exposure and nonexposed infants. Data were analysed using generalized linear models (GLMs) and multilevel mixed effects models.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>In the ZIKV cohort, age-by-exposure interactions were observed for delta (<i>p</i> = 0.027) and theta power (<i>p</i> = 0.009), where exposed infants demonstrated decreasing power with age, while nonexposed infants demonstrated increasing power with age from 3 to 12 months. In the SARS-CoV-2 cohort, antenatally exposed children had lower levels of beta (<i>p</i> = 0.022) and gamma power (<i>p</i> = 0.044) overall from 3 to 12 months. Significant recovery was observed in trajectories for beta power by 12 months.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>ZIKV exposure during pregnancy was associated with reductions in low-frequency EEG power, which may be indicative of disruptions in early brain maturation. SARS-CoV-2 exposure was associated with reductions in higher-frequency power, suggesting potential impairments on sensorimotor and cognitive integration. Increases in beta power by 12 months in the SARS-CoV-2 cohort indicate some recovery, although potential compounding and sleeper effects from early disruptions are possible.</p>\\n </section>\\n </div>\",\"PeriodicalId\":13914,\"journal\":{\"name\":\"International Journal of Developmental Neuroscience\",\"volume\":\"85 5\",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Developmental Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70047\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70047","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Whole Brain Spectral Power Differences During Infancy Following Antenatal SARS-CoV-2 and Zika Virus Exposure: Findings From Cohorts in Boston, Massachusetts and San Juan, Puerto Rico
Background
Viral exposure during pregnancy is associated with adverse outcomes in offspring. Given the increasing frequency of viral outbreaks both locally and globally, the current study sought to examine the impact of antenatal exposure to Zika virus (ZIKV) and SARS-CoV-2 on infant neurophysiological development during the first year of life.
Methods
Families were recruited from two cohorts, one in San Juan, Puerto Rico (ZIKV) and one in Boston, Massachusetts (SARS-CoV-2). For the ZIKV cohort, infants were assessed cross-sectionally between 3 to 12 months of age. For SARS-CoV-2, infants were assessed longitudinally at 3, 6, 9 and 12 months. Electroencephalography (EEG) was used to compare absolute power during a resting state task across the whole brain (by spectral band) between infants with antenatal viral exposure and nonexposed infants. Data were analysed using generalized linear models (GLMs) and multilevel mixed effects models.
Results
In the ZIKV cohort, age-by-exposure interactions were observed for delta (p = 0.027) and theta power (p = 0.009), where exposed infants demonstrated decreasing power with age, while nonexposed infants demonstrated increasing power with age from 3 to 12 months. In the SARS-CoV-2 cohort, antenatally exposed children had lower levels of beta (p = 0.022) and gamma power (p = 0.044) overall from 3 to 12 months. Significant recovery was observed in trajectories for beta power by 12 months.
Conclusion
ZIKV exposure during pregnancy was associated with reductions in low-frequency EEG power, which may be indicative of disruptions in early brain maturation. SARS-CoV-2 exposure was associated with reductions in higher-frequency power, suggesting potential impairments on sensorimotor and cognitive integration. Increases in beta power by 12 months in the SARS-CoV-2 cohort indicate some recovery, although potential compounding and sleeper effects from early disruptions are possible.
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
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