{"title":"一锅绿色合成苯并咪唑和2,3-二氢喹唑啉-4(1H)-的研究","authors":"Fadhil Faez Sead, Vicky Jain, Anjan Kumar, Subbulakshmi Ganesan, Aman Shankhyan, Girish Chandra Sharma, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas","doi":"10.1007/s10904-025-03604-y","DOIUrl":null,"url":null,"abstract":"<div><p>Benzimidazoles and 2,3-dihydroquinazolin-4(1<i>H</i>)-ones are of great interest in medicinal chemistry for their potential to develop new therapeutic agents. This research presents an innovative one-pot synthesis method for these compounds using indium oxide nanoparticles (In<sub>2</sub>O<sub>3</sub> NPs) as a catalyst, which has shown consistent efficiency and reusability over seven cycles. Glycerol is used as an environmentally friendly solvent under mild conditions. The study demonstrates that various substituents on the benzene ring do not affect reaction efficiency, resulting in high product yields. Indium oxide nanoparticles outperform previous catalysts, often leading to lower yields and longer reaction times while less reusable. The catalyst was characterized using techniques such as FT-IR, BET, TEM, XRD, and TGA, confirming its retained activity after multiple uses.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":639,"journal":{"name":"Journal of Inorganic and Organometallic Polymers and Materials","volume":"35 7","pages":"5494 - 5508"},"PeriodicalIF":4.9000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One-Pot, for the Green Preparation of Benzimidazoles and 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by In2O3 NPs/Glycerol\",\"authors\":\"Fadhil Faez Sead, Vicky Jain, Anjan Kumar, Subbulakshmi Ganesan, Aman Shankhyan, Girish Chandra Sharma, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas\",\"doi\":\"10.1007/s10904-025-03604-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Benzimidazoles and 2,3-dihydroquinazolin-4(1<i>H</i>)-ones are of great interest in medicinal chemistry for their potential to develop new therapeutic agents. This research presents an innovative one-pot synthesis method for these compounds using indium oxide nanoparticles (In<sub>2</sub>O<sub>3</sub> NPs) as a catalyst, which has shown consistent efficiency and reusability over seven cycles. Glycerol is used as an environmentally friendly solvent under mild conditions. The study demonstrates that various substituents on the benzene ring do not affect reaction efficiency, resulting in high product yields. Indium oxide nanoparticles outperform previous catalysts, often leading to lower yields and longer reaction times while less reusable. The catalyst was characterized using techniques such as FT-IR, BET, TEM, XRD, and TGA, confirming its retained activity after multiple uses.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":639,\"journal\":{\"name\":\"Journal of Inorganic and Organometallic Polymers and Materials\",\"volume\":\"35 7\",\"pages\":\"5494 - 5508\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inorganic and Organometallic Polymers and Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10904-025-03604-y\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic and Organometallic Polymers and Materials","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10904-025-03604-y","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
One-Pot, for the Green Preparation of Benzimidazoles and 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by In2O3 NPs/Glycerol
Benzimidazoles and 2,3-dihydroquinazolin-4(1H)-ones are of great interest in medicinal chemistry for their potential to develop new therapeutic agents. This research presents an innovative one-pot synthesis method for these compounds using indium oxide nanoparticles (In2O3 NPs) as a catalyst, which has shown consistent efficiency and reusability over seven cycles. Glycerol is used as an environmentally friendly solvent under mild conditions. The study demonstrates that various substituents on the benzene ring do not affect reaction efficiency, resulting in high product yields. Indium oxide nanoparticles outperform previous catalysts, often leading to lower yields and longer reaction times while less reusable. The catalyst was characterized using techniques such as FT-IR, BET, TEM, XRD, and TGA, confirming its retained activity after multiple uses.
期刊介绍：
Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.
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