同时光学测量血红蛋白，脑血流和细胞色素c -氧化酶的变化，通过波长时间复用散斑传感

IF 5.1 2区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2025-07-11 DOI:10.1109/JSTQE.2025.3588298

Tamar Dror;Victoria Tarle;Georgina Leadley;Gemma Bale;Nisan Ozana

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引用次数: 0

摘要

监测细胞色素c氧化酶（CCO）以及血红蛋白（Hb）浓度和脑血流量（CBF）的变化，为实时无创评估代谢活动提供了显著的优势。在这项研究中，我们提出了一个与CMOS相机同步的五波长激光系统，可以同时测量功能近红外光谱（fNIRS）， CCO和散斑对比光谱（SCOS）的变化。我们首先通过将时间复用激光系统与五led设置和宽带系统在幻影测量中进行比较，验证了时间复用激光系统的性能，证明了所有模式之间的强相关性。随后，我们将我们的系统应用于人体研究，以捕获同时发生的血流动力学和代谢反应，包括CCO、Hb和CBF中心脏和屏气引起的变化。

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Simultaneous Optical Measurement of Hemoglobin, Cerebral Blood Flow, and Cytochrome-C-Oxidase Changes Via Wavelength Time-Multiplexed Speckle Sensing

Monitoring cytochrome-c oxidase (CCO) alongside changes in hemoglobin (Hb) concentration and cerebral blood flow (CBF) offers significant advantages for assessing metabolic activity non-invasively in real time. In this study, we present a five-wavelength laser system synchronized with CMOS cameras, enabling simultaneous measurements of functional near-infrared spectroscopy (fNIRS), CCO and speckle contrast optical spectroscopy (SCOS) changes. We first validated the performance of our time-multiplexed laser system by comparing it with a five-LED setup and a broadband system in phantom measurements, demonstrating strong correlations across all modalities. Subsequently, we applied our system in human studies to capture concurrent hemodynamic and metabolic responses, including variations induced by cardiac and breath holding in CCO, Hb, and CBF.

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来源期刊

IEEE Journal of Selected Topics in Quantum Electronics 工程技术-工程：电子与电气

CiteScore

10.60

自引率

2.00%

发文量

212

审稿时长

3 months

期刊介绍： Papers published in the IEEE Journal of Selected Topics in Quantum Electronics fall within the broad field of science and technology of quantum electronics of a device, subsystem, or system-oriented nature. Each issue is devoted to a specific topic within this broad spectrum. Announcements of the topical areas planned for future issues, along with deadlines for receipt of manuscripts, are published in this Journal and in the IEEE Journal of Quantum Electronics. Generally, the scope of manuscripts appropriate to this Journal is the same as that for the IEEE Journal of Quantum Electronics. Manuscripts are published that report original theoretical and/or experimental research results that advance the scientific and technological base of quantum electronics devices, systems, or applications. The Journal is dedicated toward publishing research results that advance the state of the art or add to the understanding of the generation, amplification, modulation, detection, waveguiding, or propagation characteristics of coherent electromagnetic radiation having sub-millimeter and shorter wavelengths. In order to be suitable for publication in this Journal, the content of manuscripts concerned with subject-related research must have a potential impact on advancing the technological base of quantum electronic devices, systems, and/or applications. Potential authors of subject-related research have the responsibility of pointing out this potential impact. System-oriented manuscripts must be concerned with systems that perform a function previously unavailable or that outperform previously established systems that did not use quantum electronic components or concepts. Tutorial and review papers are by invitation only.