通过数值模拟开发用于COVID-19空气处理的生物活性通道

IF 3.7 3区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Bruna Iten Bittelbrunn , Harrson Silva Santana , João Lameu da Silva Junior , Dirceu Noriler , Osvaldir Pereira Taranto
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引用次数: 0

摘要

COVID-19是由SARS-CoV-2冠状病毒引起的严重呼吸道疾病,于2020年3月被宣布为大流行。这是一种高度传染性疾病,感染者呼吸、打喷嚏、咳嗽和说话时通过微小的气溶胶通过空气传播。空气传播也可发生在密闭场所,特别是在受感染者的直接环境中。因此,医院病房等环境需要不断消毒,这包括排出的空气。在此背景下,本研究数值研究了具有非均质活性表面的微流控装置吸附和灭活ICU病房排出空气中的目标物种(如病毒)的效率。一个经过验证和验证的数值模型应用于研究不同的装置配置,通过改变通道高度、入口速度和入口浓度。为了分析靶种的失活,研究了11种设计。G10设计(高1.2 x宽10 x长50 mm)在顶部和底部表面具有主动平行通道,达到了最佳性能。失活率达到45.8 %(比原始生物传感器高260倍),流速提高11倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of bioactive channels for air treatment with COVID-19 by numerical simulations
COVID-19 is a severe respiratory disease caused by SARS-CoV-2 coronavirus which was declared a pandemic in March 2020. It is a highly contagious disease transmitted through air by microscopic aerosols as infected people breath, sneeze, cough, and speak. Airborne transmission can also occur in confined places, especially in the immediate environment of the infected person. Therefore, environments such as hospital rooms need to be constantly disinfected and this includes exhaust air. In this context, the present study numerically investigates the efficiency of microfluidic devices with heterogeneous active surfaces to adsorb and deactivate target species (e.g. virus) from ICU hospital rooms exhaust air. A verified and validated numerical model was applied to investigate different device configurations by altering channel height, inlet velocity, and inlet concentrations. To analyze target species deactivation, eleven designs were studied. The best performance was achieved by G10 design (H 1.2 x W 10 x L 50 mm) with active parallel channels at top and bottom surfaces. A 45.8 % deactivation was achieved (260 times greater than the original biosensor) with an 11 times larger flow rate.
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来源期刊
Biochemical Engineering Journal
Biochemical Engineering Journal 工程技术-工程:化工
CiteScore
7.10
自引率
5.10%
发文量
380
审稿时长
34 days
期刊介绍: The Biochemical Engineering Journal aims to promote progress in the crucial chemical engineering aspects of the development of biological processes associated with everything from raw materials preparation to product recovery relevant to industries as diverse as medical/healthcare, industrial biotechnology, and environmental biotechnology. The Journal welcomes full length original research papers, short communications, and review papers* in the following research fields: Biocatalysis (enzyme or microbial) and biotransformations, including immobilized biocatalyst preparation and kinetics Biosensors and Biodevices including biofabrication and novel fuel cell development Bioseparations including scale-up and protein refolding/renaturation Environmental Bioengineering including bioconversion, bioremediation, and microbial fuel cells Bioreactor Systems including characterization, optimization and scale-up Bioresources and Biorefinery Engineering including biomass conversion, biofuels, bioenergy, and optimization Industrial Biotechnology including specialty chemicals, platform chemicals and neutraceuticals Biomaterials and Tissue Engineering including bioartificial organs, cell encapsulation, and controlled release Cell Culture Engineering (plant, animal or insect cells) including viral vectors, monoclonal antibodies, recombinant proteins, vaccines, and secondary metabolites Cell Therapies and Stem Cells including pluripotent, mesenchymal and hematopoietic stem cells; immunotherapies; tissue-specific differentiation; and cryopreservation Metabolic Engineering, Systems and Synthetic Biology including OMICS, bioinformatics, in silico biology, and metabolic flux analysis Protein Engineering including enzyme engineering and directed evolution.
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