Bruna Iten Bittelbrunn , Harrson Silva Santana , João Lameu da Silva Junior , Dirceu Noriler , Osvaldir Pereira Taranto
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Development of bioactive channels for air treatment with COVID-19 by numerical simulations
COVID-19 is a severe respiratory disease caused by SARS-CoV-2 coronavirus which was declared a pandemic in March 2020. It is a highly contagious disease transmitted through air by microscopic aerosols as infected people breath, sneeze, cough, and speak. Airborne transmission can also occur in confined places, especially in the immediate environment of the infected person. Therefore, environments such as hospital rooms need to be constantly disinfected and this includes exhaust air. In this context, the present study numerically investigates the efficiency of microfluidic devices with heterogeneous active surfaces to adsorb and deactivate target species (e.g. virus) from ICU hospital rooms exhaust air. A verified and validated numerical model was applied to investigate different device configurations by altering channel height, inlet velocity, and inlet concentrations. To analyze target species deactivation, eleven designs were studied. The best performance was achieved by G10 design (H 1.2 x W 10 x L 50 mm) with active parallel channels at top and bottom surfaces. A 45.8 % deactivation was achieved (260 times greater than the original biosensor) with an 11 times larger flow rate.
期刊介绍:
The Biochemical Engineering Journal aims to promote progress in the crucial chemical engineering aspects of the development of biological processes associated with everything from raw materials preparation to product recovery relevant to industries as diverse as medical/healthcare, industrial biotechnology, and environmental biotechnology.
The Journal welcomes full length original research papers, short communications, and review papers* in the following research fields:
Biocatalysis (enzyme or microbial) and biotransformations, including immobilized biocatalyst preparation and kinetics
Biosensors and Biodevices including biofabrication and novel fuel cell development
Bioseparations including scale-up and protein refolding/renaturation
Environmental Bioengineering including bioconversion, bioremediation, and microbial fuel cells
Bioreactor Systems including characterization, optimization and scale-up
Bioresources and Biorefinery Engineering including biomass conversion, biofuels, bioenergy, and optimization
Industrial Biotechnology including specialty chemicals, platform chemicals and neutraceuticals
Biomaterials and Tissue Engineering including bioartificial organs, cell encapsulation, and controlled release
Cell Culture Engineering (plant, animal or insect cells) including viral vectors, monoclonal antibodies, recombinant proteins, vaccines, and secondary metabolites
Cell Therapies and Stem Cells including pluripotent, mesenchymal and hematopoietic stem cells; immunotherapies; tissue-specific differentiation; and cryopreservation
Metabolic Engineering, Systems and Synthetic Biology including OMICS, bioinformatics, in silico biology, and metabolic flux analysis
Protein Engineering including enzyme engineering and directed evolution.