年龄相关性眼病的cGAS-STING通路：机制和治疗机会

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-08-15 DOI:10.1016/j.cellsig.2025.112069

Zilin Shang , Di Qin , Xiangnan Liu, Hui Li, Chang Liu, Rui Zhang, Tongyi Sun, Zhifang Pan, Weiguo Feng, Xinguo You

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引用次数: 0

摘要

环状GMP-AMP合成酶(cGAS)-干扰素基因刺激因子（STING）通路是先天免疫系统的重要组成部分，它感知细胞质中异常的双链DNA，诱导I型干扰素和促炎细胞因子的表达。在细胞衰老过程中，cGAS-STING信号通路触发衰老相关的分泌表型，从而加剧衰老现象，导致老年性眼部疾病，包括老年性黄斑变性、糖尿病性视网膜病变。本文概述了cGAS-STING信号通路的结构及其与细胞衰老的关系，并探讨了cGAS-STING与眼部衰老相关疾病的行为机制。最后，我们总结了cGAS-STING信号通路的相关抑制因子，从而为探索眼部衰老相关炎症性疾病的机制提供了新的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The cGAS-STING pathway in age-related ocular diseases: Mechanisms and therapeutic opportunities

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a crucial component of the innate immune system, which senses abnormal double-stranded DNA in the cytoplasm and induces the type I interferon and pro-inflammatory cytokines expression. In cellular senescence, the cGAS-STING signaling pathway triggers the senescence-associated secretory phenotype, thereby exacerbating the senescence phenomenon and leading to age-related ocular diseases, including age-related macular degeneration and diabetic retinopathy. Herein, we outline the structure of cGAS-STING signaling pathway and its association with cellular senescence, and discuss the mechanism of behavior between cGAS-STING and ocular aging-related diseases. Finally, we summarize the relevant inhibitors of the cGAS-STING signaling pathway, thereby offering a novel direction for exploring the mechanism of ocular aging-related inflammatory diseases.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.