微波和射频烧蚀的数值分析:一种基于电极的射频烧蚀新设计

IF 2.9 2区 生物学 Q2 BIOLOGY
Fahimeh Hamzavi, Mohammad Javad Karimi, Mahdi Bahadoran
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引用次数: 0

摘要

热消融是肝癌的一种治疗方式,利用热来破坏癌组织。采用微波消融(MWA)和射频消融(RFA)两种不同的方法对肝组织热消融过程进行了数值分析。研究了两种方法的有效性和肿瘤消融的热特性,包括温度分布、温度的时间变化、消融体积和癌组织的破坏。与RFA相比,MWA需要更短的时间来完成消融,并且可以产生更大的消融区域。此外,我们还提出并分析了一种新的基于电极的RFA设计,我们称之为诺福克松电极(NPE),它主要用于消融大的球形肿瘤。据我们所知,传统的RFA设计,利用圣诞树电极和伞形电极,在消融小于3cm的肿瘤时是有效的。然而,它们不能完全根除球形肿瘤。我们提出的NPE可以完全消融大于3cm的球形肿瘤,与传统的伞状电极设计相比,显示出更快、更有效的组织消融和更高的坏死率。这种NPE可能是肿瘤治疗领域的一个有前途和实用的进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Numerical analysis of microwave and radiofrequency ablations: A novel design for electrode-based radiofrequency ablation
Thermal ablation is a treatment modality for liver cancer that utilizes heat to destroy cancerous tissues. The numerical analysis of thermal ablation processes in liver tissue was studied using two different methods: microwave ablation (MWA) and radiofrequency ablation (RFA). The effectiveness of both methods and the thermal characteristics of tumor ablation, including temperature distribution, temporal variation in temperature, volume of ablation, and destruction of cancerous tissue, were investigated. MWA requires less time for complete ablation than RFA and can generate larger ablation zones. Additionally, a novel electrode-based design for RFA, we call it Norfolk pine electrode (NPE), which focuses on ablating large and spherical tumors, has been proposed and analyzed. To the best of our knowledge, the conventional RFA designs, which utilize the Christmas tree electrode and umbrella electrode, are effective in ablating tumors smaller than 3cm. However, they fail to completely eradicate spherical tumors. Our proposed NPE can fully ablate spherical tumors larger than 3 cm, demonstrating faster and more effective tissue ablation with higher necrosis rates than the conventional umbrella-shaped electrode designs. This NPE could be a promising and practical advancement in the realm of tumor treatment.
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来源期刊
Journal of thermal biology
Journal of thermal biology 生物-动物学
CiteScore
5.30
自引率
7.40%
发文量
196
审稿时长
14.5 weeks
期刊介绍: The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are: • The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature • The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature • Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause • Effects of temperature on reproduction and development, growth, ageing and life-span • Studies on modelling heat transfer between organisms and their environment • The contributions of temperature to effects of climate change on animal species and man • Studies of conservation biology and physiology related to temperature • Behavioural and physiological regulation of body temperature including its pathophysiology and fever • Medical applications of hypo- and hyperthermia Article types: • Original articles • Review articles
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