{"title":"眼源性动脉瘤与动脉壁血流动力学应力异常增强的关系","authors":"Li-Feng Xu, Ji-Wei Wang, Hui Li, Hao Guo, Jian-Feng Liu, Cong-Hui Li, Bu-Lang Gao","doi":"10.1016/j.jocn.2025.111564","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate hemodynamic parameters associated with ophthalmic aneurysms using computational fluid dynamic (CFD) analysis.</div></div><div><h3>Materials and methods</h3><div>Sixty patients with or without ophthalmic origin aneurysms were enrolled, including 30 patients with and 30 patients without ophthalmic aneurysms. The demography, vascular diameter and angles, and hemodynamic parameters were analyzed.</div></div><div><h3>Results</h3><div>The bifurcation angle between the ophthalmic artery and internal carotid artery (ICA) distal segment was significantly (P < 0.0001) greater in patients with than those without ophthalmic aneurysm (140.7 ± 16.3 vs. 120.8 ± 16.1). The hemodynamic parameters were all significantly decreased on aneurysm dome compared with those at the direct flow impingement zone (FIZ) after virtual aneurysm removal, including the dynamic pressure (0.36 ± 0.49 vs. 0.58 ± 0.40 Pa), total pressure (29.88 ± 3.37 vs. 32.94 ± 1.64 Pa), velocity angle (1.02 ± 1.62 vs. 1.66 ± 0.27 degree/s), vorticity (606.72 ± 254.12 vs. 853.84 ± 261.78 1/s), WSS (0.78 ± 0.30 vs. 1.11 ± 0.30 Pa), and strain rate (613.93 ± 233.21 vs. 870.78 ± 231.21 1/s). The total pressure profile was like a parabola, and the profiles of WSS and dynamic pressure were characteristic of one minimal value and two peaks. The greatest total pressure and minimal shear stress and dynamic pressure were at the FIZ center, and as blood flowed distally, the total pressure decreased rapidly while the other parameters quickly increased to peaks. The WSS peak distance was significantly (P < 0.05) positively correlated with the bifurcation angle (ophthalmic/distal ICA angle) in patients with (R = 0.59 and P = 0.004) or without (R = 0.55 and P = 0.009) ophthalmic aneurysms. The WSS peak distance was significantly (P < 0.05) positively correlated with the summit total pressure in patients with ophthalmic aneurysms (R = 0.49 and P = 0.02) rather than in patients without aneurysms or in the total patients. Transverse line 4 was located in the FIZ center, lines 1–3 on the distal ICA wall, lines 5–7 on the ophthalmic artery wall, and from transverse line 4 to line 1 or to line 7, the total pressure significantly (P < 0.0001) decreased while all the other hemodynamic parameters significantly (P < 0.0001) increased. Transverse line 5 on oe peak had significantly (P < 0.01) greater dynamic pressure, velocity angle, WSS, vorticity and strain rate than those on transverse line 3 on the other peak.</div></div><div><h3>Conclusion</h3><div>Enlarged bifurcation angle between the ophthalmic artery and distal ICA segment significantly increases the hemodynamic parameters at the bifurcation apex and may contribute to the formation of ophthalmic aneurysms, which is to decrease the abnormally elevated hemodynamic parameters at the bifurcation apex.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"141 ","pages":"Article 111564"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of ophthalmic origin aneurysms with abnormally-enhanced hemodynamic stresses at the arterial wall\",\"authors\":\"Li-Feng Xu, Ji-Wei Wang, Hui Li, Hao Guo, Jian-Feng Liu, Cong-Hui Li, Bu-Lang Gao\",\"doi\":\"10.1016/j.jocn.2025.111564\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To investigate hemodynamic parameters associated with ophthalmic aneurysms using computational fluid dynamic (CFD) analysis.</div></div><div><h3>Materials and methods</h3><div>Sixty patients with or without ophthalmic origin aneurysms were enrolled, including 30 patients with and 30 patients without ophthalmic aneurysms. The demography, vascular diameter and angles, and hemodynamic parameters were analyzed.</div></div><div><h3>Results</h3><div>The bifurcation angle between the ophthalmic artery and internal carotid artery (ICA) distal segment was significantly (P < 0.0001) greater in patients with than those without ophthalmic aneurysm (140.7 ± 16.3 vs. 120.8 ± 16.1). The hemodynamic parameters were all significantly decreased on aneurysm dome compared with those at the direct flow impingement zone (FIZ) after virtual aneurysm removal, including the dynamic pressure (0.36 ± 0.49 vs. 0.58 ± 0.40 Pa), total pressure (29.88 ± 3.37 vs. 32.94 ± 1.64 Pa), velocity angle (1.02 ± 1.62 vs. 1.66 ± 0.27 degree/s), vorticity (606.72 ± 254.12 vs. 853.84 ± 261.78 1/s), WSS (0.78 ± 0.30 vs. 1.11 ± 0.30 Pa), and strain rate (613.93 ± 233.21 vs. 870.78 ± 231.21 1/s). The total pressure profile was like a parabola, and the profiles of WSS and dynamic pressure were characteristic of one minimal value and two peaks. The greatest total pressure and minimal shear stress and dynamic pressure were at the FIZ center, and as blood flowed distally, the total pressure decreased rapidly while the other parameters quickly increased to peaks. The WSS peak distance was significantly (P < 0.05) positively correlated with the bifurcation angle (ophthalmic/distal ICA angle) in patients with (R = 0.59 and P = 0.004) or without (R = 0.55 and P = 0.009) ophthalmic aneurysms. The WSS peak distance was significantly (P < 0.05) positively correlated with the summit total pressure in patients with ophthalmic aneurysms (R = 0.49 and P = 0.02) rather than in patients without aneurysms or in the total patients. Transverse line 4 was located in the FIZ center, lines 1–3 on the distal ICA wall, lines 5–7 on the ophthalmic artery wall, and from transverse line 4 to line 1 or to line 7, the total pressure significantly (P < 0.0001) decreased while all the other hemodynamic parameters significantly (P < 0.0001) increased. Transverse line 5 on oe peak had significantly (P < 0.01) greater dynamic pressure, velocity angle, WSS, vorticity and strain rate than those on transverse line 3 on the other peak.</div></div><div><h3>Conclusion</h3><div>Enlarged bifurcation angle between the ophthalmic artery and distal ICA segment significantly increases the hemodynamic parameters at the bifurcation apex and may contribute to the formation of ophthalmic aneurysms, which is to decrease the abnormally elevated hemodynamic parameters at the bifurcation apex.</div></div>\",\"PeriodicalId\":15487,\"journal\":{\"name\":\"Journal of Clinical Neuroscience\",\"volume\":\"141 \",\"pages\":\"Article 111564\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0967586825005375\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0967586825005375","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Association of ophthalmic origin aneurysms with abnormally-enhanced hemodynamic stresses at the arterial wall
Purpose
To investigate hemodynamic parameters associated with ophthalmic aneurysms using computational fluid dynamic (CFD) analysis.
Materials and methods
Sixty patients with or without ophthalmic origin aneurysms were enrolled, including 30 patients with and 30 patients without ophthalmic aneurysms. The demography, vascular diameter and angles, and hemodynamic parameters were analyzed.
Results
The bifurcation angle between the ophthalmic artery and internal carotid artery (ICA) distal segment was significantly (P < 0.0001) greater in patients with than those without ophthalmic aneurysm (140.7 ± 16.3 vs. 120.8 ± 16.1). The hemodynamic parameters were all significantly decreased on aneurysm dome compared with those at the direct flow impingement zone (FIZ) after virtual aneurysm removal, including the dynamic pressure (0.36 ± 0.49 vs. 0.58 ± 0.40 Pa), total pressure (29.88 ± 3.37 vs. 32.94 ± 1.64 Pa), velocity angle (1.02 ± 1.62 vs. 1.66 ± 0.27 degree/s), vorticity (606.72 ± 254.12 vs. 853.84 ± 261.78 1/s), WSS (0.78 ± 0.30 vs. 1.11 ± 0.30 Pa), and strain rate (613.93 ± 233.21 vs. 870.78 ± 231.21 1/s). The total pressure profile was like a parabola, and the profiles of WSS and dynamic pressure were characteristic of one minimal value and two peaks. The greatest total pressure and minimal shear stress and dynamic pressure were at the FIZ center, and as blood flowed distally, the total pressure decreased rapidly while the other parameters quickly increased to peaks. The WSS peak distance was significantly (P < 0.05) positively correlated with the bifurcation angle (ophthalmic/distal ICA angle) in patients with (R = 0.59 and P = 0.004) or without (R = 0.55 and P = 0.009) ophthalmic aneurysms. The WSS peak distance was significantly (P < 0.05) positively correlated with the summit total pressure in patients with ophthalmic aneurysms (R = 0.49 and P = 0.02) rather than in patients without aneurysms or in the total patients. Transverse line 4 was located in the FIZ center, lines 1–3 on the distal ICA wall, lines 5–7 on the ophthalmic artery wall, and from transverse line 4 to line 1 or to line 7, the total pressure significantly (P < 0.0001) decreased while all the other hemodynamic parameters significantly (P < 0.0001) increased. Transverse line 5 on oe peak had significantly (P < 0.01) greater dynamic pressure, velocity angle, WSS, vorticity and strain rate than those on transverse line 3 on the other peak.
Conclusion
Enlarged bifurcation angle between the ophthalmic artery and distal ICA segment significantly increases the hemodynamic parameters at the bifurcation apex and may contribute to the formation of ophthalmic aneurysms, which is to decrease the abnormally elevated hemodynamic parameters at the bifurcation apex.
期刊介绍:
This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology.
The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.