{"title":"50岁以上患者牙周炎与前列腺癌和其他泌尿系统癌症相关：一项横断面研究","authors":"A-A Ajalcriña-Martensen, C-A Minchón-Medina, J Astigueta-Perez, W-G Gamboa-Vicente, L-J Ganoza-Larrea, A-S Asmat-Abanto","doi":"10.4317/medoral.27179","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Periodontitis triggers systemic inflammatory reactions that may be associated with different oncological diseases, such as prostate cancer (PC), although little information exists on the possibility of this association. To determine whether periodontitis is associated with PC and other non-metastatic urological cancers in patients over 50.</p><p><strong>Material and methods: </strong>This cross-sectional study was conducted between August and September 2024 at the outpatient clinic of the Belén de Trujillo Hospital (HBT) and the Regional Institute of Neoplastic Diseases \"Dr. Luis Pinillos Ganoza\" - IREN Norte (IREN), in Trujillo, Peru. In total, 192 patients were evaluated: 64 with PC, 64 with non-prostatic urological cancer (NPUC), and 64 with non-oncological urological disease (NOUD). Reliability was determined through inter- and intra-evaluator calibration to diagnose periodontitis, gingivitis inflammation, and plaque control. The corresponding specialist physician diagnosed PC, NPUC, and NOUD. Statistical analysis was performed using the Chi-square and Kruskal-Wallis tests, including nonparametric multiple comparison tests, with a significance level of p<0.05.</p><p><strong>Results: </strong>An association between periodontitis and PC was found in patients over 50. PC was also directly associated with moderate periodontitis (p=0.014) and generalized gingivitis inflammation (p=0.019). Concerning NPUC, an association was found with periodontal pockets of 3.5 - 5.5 mm (p=0.031) and last visit to the dentist more than one year ago (p=0.012).</p><p><strong>Conclusions: </strong>There was an association between periodontitis and PC in patients over 50. Patients with moderate periodontitis and generalized GI were more likely to present PC compared with patients with NOUD. In addition, there was a greater probability of presenting PC versus NPUC in patients with periodontal pockets of 3.5-5.5 mm and in those whose last visit to the dentist was more than one year ago.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e681-e689"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395600/pdf/","citationCount":"0","resultStr":"{\"title\":\"Periodontitis associated with prostate cancer and other urological cancers in patients over 50 years of age: a cross-sectional study.\",\"authors\":\"A-A Ajalcriña-Martensen, C-A Minchón-Medina, J Astigueta-Perez, W-G Gamboa-Vicente, L-J Ganoza-Larrea, A-S Asmat-Abanto\",\"doi\":\"10.4317/medoral.27179\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Periodontitis triggers systemic inflammatory reactions that may be associated with different oncological diseases, such as prostate cancer (PC), although little information exists on the possibility of this association. To determine whether periodontitis is associated with PC and other non-metastatic urological cancers in patients over 50.</p><p><strong>Material and methods: </strong>This cross-sectional study was conducted between August and September 2024 at the outpatient clinic of the Belén de Trujillo Hospital (HBT) and the Regional Institute of Neoplastic Diseases \\\"Dr. Luis Pinillos Ganoza\\\" - IREN Norte (IREN), in Trujillo, Peru. In total, 192 patients were evaluated: 64 with PC, 64 with non-prostatic urological cancer (NPUC), and 64 with non-oncological urological disease (NOUD). Reliability was determined through inter- and intra-evaluator calibration to diagnose periodontitis, gingivitis inflammation, and plaque control. The corresponding specialist physician diagnosed PC, NPUC, and NOUD. Statistical analysis was performed using the Chi-square and Kruskal-Wallis tests, including nonparametric multiple comparison tests, with a significance level of p<0.05.</p><p><strong>Results: </strong>An association between periodontitis and PC was found in patients over 50. PC was also directly associated with moderate periodontitis (p=0.014) and generalized gingivitis inflammation (p=0.019). Concerning NPUC, an association was found with periodontal pockets of 3.5 - 5.5 mm (p=0.031) and last visit to the dentist more than one year ago (p=0.012).</p><p><strong>Conclusions: </strong>There was an association between periodontitis and PC in patients over 50. Patients with moderate periodontitis and generalized GI were more likely to present PC compared with patients with NOUD. In addition, there was a greater probability of presenting PC versus NPUC in patients with periodontal pockets of 3.5-5.5 mm and in those whose last visit to the dentist was more than one year ago.</p>\",\"PeriodicalId\":49016,\"journal\":{\"name\":\"Medicina Oral Patologia Oral Y Cirugia Bucal\",\"volume\":\" \",\"pages\":\"e681-e689\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395600/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina Oral Patologia Oral Y Cirugia Bucal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4317/medoral.27179\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.27179","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
背景：牙周炎引发的全身炎症反应可能与不同的肿瘤疾病有关，如前列腺癌（PC），尽管关于这种关联的可能性的信息很少。目的：确定50岁以上患者牙周炎是否与前列腺癌和其他非转移性泌尿系统癌症相关。材料和方法：这项横断面研究于2024年8月至9月在秘鲁特鲁希略bel de Trujillo医院（HBT）和区域肿瘤疾病研究所"Dr. Luis Pinillos Ganoza" - IREN Norte （IREN）的门诊进行。共有192例患者被评估：64例PC， 64例非前列腺性泌尿系统癌（NPUC）， 64例非肿瘤性泌尿系统疾病（NOUD）。通过评估者之间和评估者内部的校准来确定诊断牙周炎、牙龈炎炎症和菌斑控制的可靠性。相应专科医师诊断为PC、NPUC、NOUD。统计学分析采用卡方检验和Kruskal-Wallis检验，包括非参数多重比较检验，具有显著性水平结果：在50岁以上的患者中发现牙周炎与PC之间存在关联。PC还与中度牙周炎（p=0.014）和全身性牙龈炎炎症（p=0.019）直接相关。NPUC与牙周袋尺寸为3.5 ~ 5.5 mm （p=0.031）和最后一次去看牙医时间超过一年（p=0.012）有关。结论：50岁以上患者牙周炎与PC有相关性。与NOUD患者相比，中度牙周炎和广泛性GI患者更容易出现PC。此外，在牙周袋为3.5-5.5 mm的患者和上次看牙医超过一年的患者中，出现PC的可能性比出现NPUC的可能性更大。
Periodontitis associated with prostate cancer and other urological cancers in patients over 50 years of age: a cross-sectional study.
Background: Periodontitis triggers systemic inflammatory reactions that may be associated with different oncological diseases, such as prostate cancer (PC), although little information exists on the possibility of this association. To determine whether periodontitis is associated with PC and other non-metastatic urological cancers in patients over 50.
Material and methods: This cross-sectional study was conducted between August and September 2024 at the outpatient clinic of the Belén de Trujillo Hospital (HBT) and the Regional Institute of Neoplastic Diseases "Dr. Luis Pinillos Ganoza" - IREN Norte (IREN), in Trujillo, Peru. In total, 192 patients were evaluated: 64 with PC, 64 with non-prostatic urological cancer (NPUC), and 64 with non-oncological urological disease (NOUD). Reliability was determined through inter- and intra-evaluator calibration to diagnose periodontitis, gingivitis inflammation, and plaque control. The corresponding specialist physician diagnosed PC, NPUC, and NOUD. Statistical analysis was performed using the Chi-square and Kruskal-Wallis tests, including nonparametric multiple comparison tests, with a significance level of p<0.05.
Results: An association between periodontitis and PC was found in patients over 50. PC was also directly associated with moderate periodontitis (p=0.014) and generalized gingivitis inflammation (p=0.019). Concerning NPUC, an association was found with periodontal pockets of 3.5 - 5.5 mm (p=0.031) and last visit to the dentist more than one year ago (p=0.012).
Conclusions: There was an association between periodontitis and PC in patients over 50. Patients with moderate periodontitis and generalized GI were more likely to present PC compared with patients with NOUD. In addition, there was a greater probability of presenting PC versus NPUC in patients with periodontal pockets of 3.5-5.5 mm and in those whose last visit to the dentist was more than one year ago.
期刊介绍：
1. Oral Medicine and Pathology:
Clinicopathological as well as medical or surgical management aspects of
diseases affecting oral mucosa, salivary glands, maxillary bones, as well as
orofacial neurological disorders, and systemic conditions with an impact on
the oral cavity.
2. Oral Surgery:
Surgical management aspects of diseases affecting oral mucosa, salivary glands,
maxillary bones, teeth, implants, oral surgical procedures. Surgical management
of diseases affecting head and neck areas.
3. Medically compromised patients in Dentistry:
Articles discussing medical problems in Odontology will also be included, with
a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients.
4. Implantology
5. Periodontology
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