{"title":"大唾液腺的转移性黑色素瘤-系统综述。","authors":"P-H Rizzardi, A de Farias Gabriel, I-D Martins, V-C Carrard, V-G Zanella, F-M Girardi, M-A Martins, V-P Wagner, M-D Martins, L-F Schuch","doi":"10.4317/medoral.27216","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Metastatic melanoma of the major salivary gland has been rarely reported in the literature. Thus, the aim of this study was to integrate all data about the clinical, sociodemographic, histopathological, treatment, and follow-up characteristics of metastatic melanoma of the major salivary glands.</p><p><strong>Material and methods: </strong>Electronic searches were performed in five databases and the grey literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Case reports or case series describing metastatic melanoma of the major salivary gland without language or year of publication restriction were included.</p><p><strong>Results: </strong>Twenty-five studies reporting 47 cases of metastatic melanoma were identified. The mean patient age at diagnosis was 56.321.5 years, mainly occurring in men (70.2%). The site of the primary melanoma was mostly in the head and neck region (65%) and the parotid (93.6%) was the most affected major salivary gland by metastatic lesions. Parotidectomy was the main treatment choice. The overall 1- and 5-year survival rates were 79% and 45%, respectively.</p><p><strong>Conclusions: </strong>Metastatic melanoma of the major salivary gland is an uncommon phenomenon involving a poor prognosis.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e736-e744"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395568/pdf/","citationCount":"0","resultStr":"{\"title\":\"Metastatic melanoma of the major salivary glands - a systematic review.\",\"authors\":\"P-H Rizzardi, A de Farias Gabriel, I-D Martins, V-C Carrard, V-G Zanella, F-M Girardi, M-A Martins, V-P Wagner, M-D Martins, L-F Schuch\",\"doi\":\"10.4317/medoral.27216\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Metastatic melanoma of the major salivary gland has been rarely reported in the literature. Thus, the aim of this study was to integrate all data about the clinical, sociodemographic, histopathological, treatment, and follow-up characteristics of metastatic melanoma of the major salivary glands.</p><p><strong>Material and methods: </strong>Electronic searches were performed in five databases and the grey literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Case reports or case series describing metastatic melanoma of the major salivary gland without language or year of publication restriction were included.</p><p><strong>Results: </strong>Twenty-five studies reporting 47 cases of metastatic melanoma were identified. The mean patient age at diagnosis was 56.321.5 years, mainly occurring in men (70.2%). The site of the primary melanoma was mostly in the head and neck region (65%) and the parotid (93.6%) was the most affected major salivary gland by metastatic lesions. Parotidectomy was the main treatment choice. The overall 1- and 5-year survival rates were 79% and 45%, respectively.</p><p><strong>Conclusions: </strong>Metastatic melanoma of the major salivary gland is an uncommon phenomenon involving a poor prognosis.</p>\",\"PeriodicalId\":49016,\"journal\":{\"name\":\"Medicina Oral Patologia Oral Y Cirugia Bucal\",\"volume\":\" \",\"pages\":\"e736-e744\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395568/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina Oral Patologia Oral Y Cirugia Bucal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4317/medoral.27216\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.27216","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Metastatic melanoma of the major salivary glands - a systematic review.
Background: Metastatic melanoma of the major salivary gland has been rarely reported in the literature. Thus, the aim of this study was to integrate all data about the clinical, sociodemographic, histopathological, treatment, and follow-up characteristics of metastatic melanoma of the major salivary glands.
Material and methods: Electronic searches were performed in five databases and the grey literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Case reports or case series describing metastatic melanoma of the major salivary gland without language or year of publication restriction were included.
Results: Twenty-five studies reporting 47 cases of metastatic melanoma were identified. The mean patient age at diagnosis was 56.321.5 years, mainly occurring in men (70.2%). The site of the primary melanoma was mostly in the head and neck region (65%) and the parotid (93.6%) was the most affected major salivary gland by metastatic lesions. Parotidectomy was the main treatment choice. The overall 1- and 5-year survival rates were 79% and 45%, respectively.
Conclusions: Metastatic melanoma of the major salivary gland is an uncommon phenomenon involving a poor prognosis.
期刊介绍：
1. Oral Medicine and Pathology:
Clinicopathological as well as medical or surgical management aspects of
diseases affecting oral mucosa, salivary glands, maxillary bones, as well as
orofacial neurological disorders, and systemic conditions with an impact on
the oral cavity.
2. Oral Surgery:
Surgical management aspects of diseases affecting oral mucosa, salivary glands,
maxillary bones, teeth, implants, oral surgical procedures. Surgical management
of diseases affecting head and neck areas.
3. Medically compromised patients in Dentistry:
Articles discussing medical problems in Odontology will also be included, with
a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients.
4. Implantology
5. Periodontology
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